TY - JOUR
T1 - Antioxidant biomarkers and cardio-metabolic risk markers in an Aboriginal community in remote Australia
T2 - a cross-sectional study
AU - Knudsen, Lenette
AU - Lyons, Jasmine G
AU - O'Dea, Kerin
AU - Christensen, Dirk L
AU - Brimblecombe, Julie K
PY - 2021/10
Y1 - 2021/10
N2 - OBJECTIVE: High-quality diets, characterised by nutrient-rich foods, are one of the foundations for health and well-being. Indicators of diet quality, antioxidants, are associated with protection against cardiometabolic diseases. The current study explores relationships between plasma antioxidants and cardiometabolic risk among Aboriginal people in Australia.DESIGN: As part of a community-driven health promotion programme, we conducted a cross-sectional study including a health-behaviour questionnaire, plasma antioxidants and cardiometabolic risk markers (anthropometric, blood pressure measurements, fasting glucose, glycated Hb (HbA1c), lipids, C-reactive protein and albumin-creatinine-ratio) continuous and categorised into population-specific cut-offs. Antioxidants (β-carotene, β-cryptoxanthin, lycopene, lutein-zeaxanthin, retinol and α-tocopherol measured using HPLC) were applied to a principal component analysis, which aggregated these into a single component. Linear regression models were applied to investigate associations between the antioxidant component and cardiometabolic risk markers.SETTING: Community in a remote area in Northern Territory, Australia.PARTICIPANTS: A total of 324 Aboriginal people, mean age 35·5 (range 15-75) years.RESULTS: Antioxidant component levels were higher among individuals with higher self-reported vegetable intake (P < 0·01), higher among individuals with higher self-reported fruit intake (P = 0·05) and lower among current smokers (P = 0·06). Linear regression revealed an inverse association between the antioxidant component and C-reactive protein (β = -0·01, P < 0·01) after adjusting for confounders.CONCLUSION: Higher plasma antioxidant levels, indicators of diet quality, were associated with lower levels of high-sensitivity C-reactive protein in this Aboriginal population in remote Australia. This association suggests plasma antioxidants may be protective against inflammation; however, longitudinal studies are needed to examine this potentially protective relationship.
AB - OBJECTIVE: High-quality diets, characterised by nutrient-rich foods, are one of the foundations for health and well-being. Indicators of diet quality, antioxidants, are associated with protection against cardiometabolic diseases. The current study explores relationships between plasma antioxidants and cardiometabolic risk among Aboriginal people in Australia.DESIGN: As part of a community-driven health promotion programme, we conducted a cross-sectional study including a health-behaviour questionnaire, plasma antioxidants and cardiometabolic risk markers (anthropometric, blood pressure measurements, fasting glucose, glycated Hb (HbA1c), lipids, C-reactive protein and albumin-creatinine-ratio) continuous and categorised into population-specific cut-offs. Antioxidants (β-carotene, β-cryptoxanthin, lycopene, lutein-zeaxanthin, retinol and α-tocopherol measured using HPLC) were applied to a principal component analysis, which aggregated these into a single component. Linear regression models were applied to investigate associations between the antioxidant component and cardiometabolic risk markers.SETTING: Community in a remote area in Northern Territory, Australia.PARTICIPANTS: A total of 324 Aboriginal people, mean age 35·5 (range 15-75) years.RESULTS: Antioxidant component levels were higher among individuals with higher self-reported vegetable intake (P < 0·01), higher among individuals with higher self-reported fruit intake (P = 0·05) and lower among current smokers (P = 0·06). Linear regression revealed an inverse association between the antioxidant component and C-reactive protein (β = -0·01, P < 0·01) after adjusting for confounders.CONCLUSION: Higher plasma antioxidant levels, indicators of diet quality, were associated with lower levels of high-sensitivity C-reactive protein in this Aboriginal population in remote Australia. This association suggests plasma antioxidants may be protective against inflammation; however, longitudinal studies are needed to examine this potentially protective relationship.
KW - Indigenous people
KW - Key words:
KW - Plasma antioxidants
KW - cardio-metabolic risk
KW - nutrition
KW - quality of diet
UR - http://www.scopus.com/inward/record.url?scp=85097281014&partnerID=8YFLogxK
U2 - 10.1017/S1368980020004899
DO - 10.1017/S1368980020004899
M3 - Journal article
C2 - 33261694
SN - 1368-9800
VL - 24
SP - 4937
EP - 4948
JO - Public Health Nutrition
JF - Public Health Nutrition
IS - 15
ER -