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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Antimicrobial Tolerance and Metabolic Adaptations in Microbial Biofilms

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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Vis graf over relationer

Active bacterial metabolism is a prerequisite for optimal activity of many classes of antibiotics. Hence, bacteria have developed strategies to reduce or modulate metabolic pathways to become tolerant. This review describes the tight relationship between metabolism and tolerance in bacterial biofilms, and how physicochemical properties of the microenvironment at the host-pathogen interface (such as oxygen and nutritional content) are key to this relationship. Understanding how metabolic adaptations lead to tolerance brings us to novel approaches to tackle antibiotic-tolerant biofilms. We describe the use of hyperbaric oxygen therapy, metabolism-stimulating metabolites, and alternative strategies to redirect bacterial metabolism towards an antibiotic-susceptible phenotype.

OriginalsprogEngelsk
TidsskriftTrends in Microbiology
Vol/bind27
Udgave nummer10
Sider (fra-til)850-863
Antal sider14
ISSN0966-842X
DOI
StatusUdgivet - okt. 2019

Bibliografisk note

Copyright © 2019 Elsevier Ltd. All rights reserved.

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