Antimicrobial activity of peptidomimetics against multidrug-resistant Escherichia coli: a comparative study of different backbones

Rasmus Jahnsen, Niels Frimodt-Møller, Henrik Franzyk

69 Citationer (Scopus)

Abstract

Novel remedies in the battle against multidrug-resistant bacterial strains are urgently needed, and one obvious approach involves antimicrobial peptides and mimics hereof. The impact of α- and β-peptoid as well as β(3)-amino acid modifications on the activity profile against β-lactamase-producing Escherichia coli was assessed by testing an array comprising different types of cationic peptidomimetics obtained by a general monomer-based solid-phase synthesis protocol. Most of the peptidomimetics possessed high to moderate activity toward multidrug-resistant E. coli as opposed to the corresponding inactive peptides. Nevertheless, differences in hemolytic activities indicate that a careful choice of backbone design constitutes a significant parameter in the search for effective cationic antimicrobial peptidomimetics targeting specific bacteria.
OriginalsprogEngelsk
TidsskriftJournal of Medicinal Chemistry
Vol/bind55
Udgave nummer16
Sider (fra-til)7253-61
Antal sider9
ISSN0022-2623
DOI
StatusUdgivet - 23 aug. 2012

Fingeraftryk

Dyk ned i forskningsemnerne om 'Antimicrobial activity of peptidomimetics against multidrug-resistant Escherichia coli: a comparative study of different backbones'. Sammen danner de et unikt fingeraftryk.

Citationsformater