Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Antihypertensive Drugs and Risk of Depression: A Nationwide Population-Based Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Data Sharing Under the General Data Protection Regulation: Time to Harmonize Law and Research Ethics?

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Predictive Importance of Blood Pressure Characteristics With Increasing Age in Healthy Men and Women: The MORGAM Project

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Association of Fatal and Nonfatal Cardiovascular Outcomes With 24-Hour Mean Arterial Pressure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Does Estimated Pulse Wave Velocity Add Prognostic Information? MORGAM Prospective Cohort Project

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Risk of Developing Hypokalemia in Patients With Hypertension Treated With Combination Antihypertensive Therapy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Clopidogrel, prasugrel, and ticagrelor for all-comers with ST-segment elevation myocardial infarction

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Nationwide cardiovascular disease admission rates during a second COVID-19 lockdown

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  3. Workforce Attachment after Ischemic Stroke – The Importance of Time to Thrombolytic Therapy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Hypertension, cardiovascular diseases, and cerebrovascular diseases are associated with an increased risk of depression, but it remains unclear whether treatment with antihypertensive agents decreases or increases this risk. The effects of individual drugs are also unknown. We used Danish population-based registers to systematically investigate whether the 41 most used individual antihypertensive drugs were associated with an altered risk of incident depression. Analyses of diuretics were included for comparisons. Participants were included in the study in January 2005 and followed until December 2015. Two different outcome measures were included: (1) a diagnosis of depressive disorder at a psychiatric hospital as an inpatient or outpatient and (2) a combined measure of a diagnosis of depression or use of antidepressants. Continued use of classes of angiotensin agents, calcium antagonists, and β-blockers was associated with significantly decreased rates of depression, whereas diuretic use was not. Individual drugs associated with decreased depression included 2 of 16 angiotensin agents: enalapril and ramipril; 3 of 10 calcium antagonists: amlodipine, verapamil, and verapamil combinations; and 4 of 15 β-blockers: propranolol, atenolol, bisoprolol, and carvedilol. No drug was associated with an increased risk of depression. In conclusion, real-life population-based data suggest a positive effect of continued use of 9 individual antihypertensive agents. This evidence should be used in guiding prescriptions for patients at risk of developing depression including those with prior depression or anxiety and patients with a family history of depression.

OriginalsprogEngelsk
TidsskriftHypertension
Vol/bind76
Udgave nummer4
Sider (fra-til)1263-1279
Antal sider17
ISSN0194-911X
DOI
StatusUdgivet - okt. 2020

ID: 60949280