Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Anti-dopamine D2 receptor antibodies in chronic tic disorders

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Specialist health care services use in a European cohort of infants born very preterm

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Muscle growth is reduced in 15-month-old children with cerebral palsy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Challenges in conducting paediatric trials with off-patent drugs

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. An observational study of emotion regulation in children with Tourette syndrome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Synaptic processes and immune-related pathways implicated in Tourette syndrome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Francesco Addabbo
  • Valentina Baglioni
  • Anette Schrag
  • Markus J Schwarz
  • Andrea Dietrich
  • Pieter J Hoekstra
  • Davide Martino
  • Maura Buttiglione
  • EMTICS Collaborative Group
Vis graf over relationer
Aim: To investigate the association between circulating anti-dopamine D2 receptor (D2R) autoantibodies and the exacerbation of tics in children with chronic tic disorders (CTDs). Method: One hundred and thirty-seven children with CTDs (108 males, 29 females; mean age [SD] 10y 0mo [2y 7mo], range 4-16y) were recruited over 18 months. Patients were assessed at baseline, at tic exacerbation, and at 2 months after exacerbation. Serum anti-D2R antibodies were evaluated using a cell-based assay and blinded immunofluorescence microscopy scoring was performed by two raters. The association between visit type and presence of anti-D2R antibodies was measured with McNemar's test and repeated-measure logistic regression models, adjusting for potential demographic and clinical confounders. Results: At exacerbation, 11 (8%) participants became anti-D2R-positive ('early peri-exacerbation seroconverters'), and nine (6.6%) became anti-D2R-positive at post-exacerbation ('late peri-exacerbation seroconverters'). The anti-D2R antibodies were significantly associated with exacerbations when compared to baseline (McNemar's odds ratio=11, p=0.003) and conditional logistic regression confirmed this association (Z=3.49, p<0.001) after adjustment for demographic and clinical data and use of psychotropic drugs. Interpretation: There is a potential association between immune mechanisms and the severity course of tics in adolescents with CTDs.
OriginalsprogEngelsk
TidsskriftDevelopmental Medicine and Child Neurology
Vol/bind62
Udgave nummer10
Sider (fra-til)1205-1212
Antal sider8
ISSN0012-1622
DOI
StatusUdgivet - okt. 2020

Bibliografisk note

© 2020 Mac Keith Press.

ID: 62293560