Antibiotic prophylaxis in high risk biliary surgery: one dose of ceftriaxone compared with two doses of cefuroxime

A Hjortrup, F Moesgaard, F Jensen, C Johansen, R Nielsen

Abstract

In a controlled trial 219 high risk patients undergoing biliary surgery were allocated at random by sealed envelopes to one of two treatment groups. Group I (n = 112) received a single dose ceftriaxone 1 g intravenously at the time of skin incision, and group II (n = 107) was given cefuroxime 1.5 g intravenously at the time of skin incision, followed by a second dose eight hours later. There were no significant differences between groups in age, sex, diagnosis, or operations carried out. There were three wound infections in group I (3%) and four in group II (4%) (p = 0.65). One patient in group I and two patients in group II developed intra-abdominal abscess and septicaemia (0.9% and 1.9%, respectively). Five patients developed pneumonia postoperatively in group I (5%) and six in group II (6%) (p = 0.65). There was no significant difference of the total number of postoperative infectious complications (wound infection, intraabdominal abscess, septicaemia, and pneumonia) between the groups (p = 0.42). A single dose of ceftriaxone given intravenously at skin incision was as effective as two doses of cefuroxime for the prophylaxis of wound infection in this high risk group of patients.

OriginalsprogEngelsk
TidsskriftThe European journal of surgery = Acta chirurgica
Vol/bind157
Udgave nummer6-7
Sider (fra-til)403-5
Antal sider3
ISSN1102-4151
StatusUdgivet - 1991
Udgivet eksterntJa

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