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Antibiofilm Properties of Acetic Acid

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@article{5be00f36ea1947e28c098c9500c87f89,
title = "Antibiofilm Properties of Acetic Acid",
abstract = "Bacterial biofilms are known to be extremely tolerant toward antibiotics and other antimicrobial agents. These biofilms cause the persistence of chronic infections. Since antibiotics rarely resolve these infections, the only effective treatment of chronic infections is surgical removal of the infected implant, tissue, or organ and thereby the biofilm. Acetic acid is known for its antimicrobial effect on bacteria in general, but has never been thoroughly tested for its efficacy against bacterial biofilms. In this article, we describe complete eradication of both Gram-positive and Gram-negative biofilms using acetic acid both as a liquid and as a dry salt. In addition, we present our clinical experience of acetic acid treatment of chronic wounds. In conclusion, we here present the first comprehensive in vitro and in vivo testing of acetic acid against bacterial biofilms.",
author = "Thomas Bjarnsholt and Morten Alhede and Jensen, {Peter {\O}strup} and Nielsen, {Anne K} and Johansen, {Helle Krogh} and Preben Hom{\o}e and Niels H{\o}iby and Michael Givskov and Klaus Kirketerp-M{\o}ller",
year = "2015",
month = "7",
day = "1",
doi = "10.1089/wound.2014.0554",
language = "English",
volume = "4",
pages = "363--372",
journal = "Advances in Wound Care",
issn = "2162-1918",
publisher = "Mary AnnLiebert, Inc. Publishers",
number = "7",

}

RIS

TY - JOUR

T1 - Antibiofilm Properties of Acetic Acid

AU - Bjarnsholt, Thomas

AU - Alhede, Morten

AU - Jensen, Peter Østrup

AU - Nielsen, Anne K

AU - Johansen, Helle Krogh

AU - Homøe, Preben

AU - Høiby, Niels

AU - Givskov, Michael

AU - Kirketerp-Møller, Klaus

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Bacterial biofilms are known to be extremely tolerant toward antibiotics and other antimicrobial agents. These biofilms cause the persistence of chronic infections. Since antibiotics rarely resolve these infections, the only effective treatment of chronic infections is surgical removal of the infected implant, tissue, or organ and thereby the biofilm. Acetic acid is known for its antimicrobial effect on bacteria in general, but has never been thoroughly tested for its efficacy against bacterial biofilms. In this article, we describe complete eradication of both Gram-positive and Gram-negative biofilms using acetic acid both as a liquid and as a dry salt. In addition, we present our clinical experience of acetic acid treatment of chronic wounds. In conclusion, we here present the first comprehensive in vitro and in vivo testing of acetic acid against bacterial biofilms.

AB - Bacterial biofilms are known to be extremely tolerant toward antibiotics and other antimicrobial agents. These biofilms cause the persistence of chronic infections. Since antibiotics rarely resolve these infections, the only effective treatment of chronic infections is surgical removal of the infected implant, tissue, or organ and thereby the biofilm. Acetic acid is known for its antimicrobial effect on bacteria in general, but has never been thoroughly tested for its efficacy against bacterial biofilms. In this article, we describe complete eradication of both Gram-positive and Gram-negative biofilms using acetic acid both as a liquid and as a dry salt. In addition, we present our clinical experience of acetic acid treatment of chronic wounds. In conclusion, we here present the first comprehensive in vitro and in vivo testing of acetic acid against bacterial biofilms.

U2 - 10.1089/wound.2014.0554

DO - 10.1089/wound.2014.0554

M3 - Journal article

VL - 4

SP - 363

EP - 372

JO - Advances in Wound Care

JF - Advances in Wound Care

SN - 2162-1918

IS - 7

ER -

ID: 45583404