Abstract
This article discusses the rationale behind recommending immunopharmacological guidance of long-term therapies with genetically engineered anti-TNF-α immunoglobulin constructs. Arguments why therapeutic decision-making should not rely on clinical outcome alone are presented. Central to this is that the use of theranostics (i.e., monitoring circulating levels of functional anti-TNF-α drugs and antidrug antibodies) would markedly improve treatment because therapies can be tailored to individual patients and provide more effective and economical long-term therapies with minimal risk of side effects. Large-scale immunopharmacological knowledge of how patients 'handle' TNF-α biopharmaceuticals would also help industry develop more effective and safer TNF-α inhibitors.
Originalsprog | Engelsk |
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Tidsskrift | Immunotherapy |
Vol/bind | 4 |
Udgave nummer | 11 |
Sider (fra-til) | 1167-79 |
Antal sider | 13 |
ISSN | 1750-743X |
DOI | |
Status | Udgivet - 2012 |