Anti-TNF-α biotherapies: perspectives for evidence-based personalized medicine

Klaus Bendtzen

    54 Citationer (Scopus)

    Abstract

    This article discusses the rationale behind recommending immunopharmacological guidance of long-term therapies with genetically engineered anti-TNF-α immunoglobulin constructs. Arguments why therapeutic decision-making should not rely on clinical outcome alone are presented. Central to this is that the use of theranostics (i.e., monitoring circulating levels of functional anti-TNF-α drugs and antidrug antibodies) would markedly improve treatment because therapies can be tailored to individual patients and provide more effective and economical long-term therapies with minimal risk of side effects. Large-scale immunopharmacological knowledge of how patients 'handle' TNF-α biopharmaceuticals would also help industry develop more effective and safer TNF-α inhibitors.
    OriginalsprogEngelsk
    TidsskriftImmunotherapy
    Vol/bind4
    Udgave nummer11
    Sider (fra-til)1167-79
    Antal sider13
    ISSN1750-743X
    DOI
    StatusUdgivet - 2012

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