TY - JOUR
T1 - Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis
AU - Leonardi, Craig
AU - Matheson, Robert
AU - Zachariae, Claus
AU - Cameron, Gregory
AU - Li, Linda
AU - Edson-Heredia, Emily
AU - Braun, Daniel
AU - Banerjee, Subhashis
PY - 2012
Y1 - 2012
N2 - Type 17 helper T cells have been suggested to play a pathological role in psoriasis. They secrete several proinflammatory cytokines, including interleukin-17A (also known as interleukin-17). We evaluated the safety and efficacy of ixekizumab (LY2439821), a humanized anti-interleukin-17 monoclonal antibody, for psoriasis treatment.
AB - Type 17 helper T cells have been suggested to play a pathological role in psoriasis. They secrete several proinflammatory cytokines, including interleukin-17A (also known as interleukin-17). We evaluated the safety and efficacy of ixekizumab (LY2439821), a humanized anti-interleukin-17 monoclonal antibody, for psoriasis treatment.
U2 - 10.1056/NEJMoa1109997
DO - 10.1056/NEJMoa1109997
M3 - Journal article
C2 - 22455413
SN - 0028-4793
VL - 366
SP - 1190
EP - 1199
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 13
ER -