Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Anterior lamina cribrosa surface position in idiopathic intracranial hypertension and glaucoma

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

DOI

  1. Intracranial pressure and optic disc changes in a rat model of obstructive hydrocephalus

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  2. Increased incidence of mental disorders in children with cataract - findings from a population-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  3. Socio-economic status in families affected by childhood cataract

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  4. Medicinsk behandling af åbenvinklet glaukom

    Publikation: Bidrag til tidsskriftReviewpeer review

Vis graf over relationer

PURPOSE: To compare the anterior lamina cribrosa (LC) surface position in patients with idiopathic intracranial hypertension (IIH), primary open-angle glaucoma (high-tension glaucoma [HTG] and normal-tension glaucoma [NTG]), and healthy controls using enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT).

METHODS: This was a retrospective, cross-sectional observational study of 11 eyes with IIH, 20 eyes with HTG, 20 eyes with NTG, and 37 control eyes. Serial horizontal B-scans of the optic nerve head were obtained using EDI-OCT. The LC depth, defined as the distance from the Bruch membrane opening plane to the anterior LC surface, was manually measured on selected B-scans covering the central three-quarters of the optic nerve head in each eye.

RESULTS: Mean LC depth in patients with IIH (325.2 ± 92.1 µm) was significantly (p<0.01) decreased compared to control subjects (387.8 ± 53.9 µm). In HTG, the mean LC depth (493.0 ± 115.2 µm) was significantly increased compared to NTG (376.6 ± 27.1 µm, p<0.05) and control subjects (332.7 ± 53.1 µm, p<0.001). The trans-LC pressure difference (TLPD) (intraocular pressure - cerebrospinal fluid pressure) was positively correlated with the LC depth (r = 0.96, p<0.001) and inversely correlated with visual field perimetric mean deviation in patients with IIH (r = -0.88, p<0.001).

CONCLUSIONS: The LC is positioned anteriorly in patients with IIH and posteriorly in glaucomatous eyes compared to normal controls. The positional changes of the LC could be a result of the TLPD between the intraocular and intracranial pressure compartments.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Ophthalmology
Vol/bind27
Udgave nummer1
Sider (fra-til)55-61
DOI
StatusUdgivet - 16 maj 2017

ID: 46487121