Antenatal bestemmelse af føtal RhD-blodtype baseret på føtalt DNA i plasma fra den RhD-negative mor--sekundaerpublikation

Frederik Banch Clausen, Grethe Risum Krog, Klaus Rieneck, Leif Kofoed Nielsen, Rasmus Lundquist, Kirsten Finning, Ebbe Dickmeiss, Morten Hedegaard, Morten Hanefeld Dziegiel

2 Citationer (Scopus)

Abstract

We present a reliable test for prenatal prediction of fetal RhD type using maternal plasma from RhD-women. This test is needed for a future antenatal RH prophylaxis. A new real time PCR based assay targeting RHD exon 7 and a published assay for RHD exon 10 were used to determine the fetal RHD status in DNA extracted from plasma from 56 pregnant women in 15th-36th week of gestation. Prediction of fetal RhD type was compared with the phenotype determined after birth, and showed 100% concordance. This setup will be of value in antenatal RH prophylaxis and in the management of immunised women.

Bidragets oversatte titelAntenatal determination of fetal RhD-blood type based on fetal DNA in plasma from the RhD-negative mother--secondary publication
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind168
Udgave nummer26-32
Sider (fra-til)2568-70
Antal sider3
ISSN0041-5782
StatusUdgivet - 26 jun. 2006

Emneord

  • DNA
  • DNA Probes
  • Exons
  • Female
  • Fetal Diseases
  • Genotype
  • Humans
  • Polymerase Chain Reaction
  • Pregnancy
  • Prenatal Diagnosis
  • Rh-Hr Blood-Group System
  • Sensitivity and Specificity

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