Annexin A2 and cancer: A systematic review

Maria V Christensen, Claus K Høgdall, Kirsten M Jochumsen, Estrid V S Høgdall

117 Citationer (Scopus)

Abstract

Annexin A2 is a 36-kDa protein interfering with multiple cellular processes especially in cancer progression. The present review aimed to show the relations between Annexin A2 and cancer. A systematic search for studies investigating cancer and Annexin A2 expression was conducted using PubMed. Acute lymphoblastic leukaemia, acute promyelocytic leukaemia, clear cell renal cell carcinoma, breast, cervical, colorectal, endometrial, gastric cancer, glioblastoma, hepatocellular carcinoma, lung, multiple myeloma, oesophageal squamous cell carcinoma, ovarian cancer, pancreatic duct adenocarcinoma, prostate cancer and urothelial carcinoma were evaluated. Annexin A2 expression correlates with resistance to treatment, binding to the bone marrow, histological grade and type, TNM-stage and shortened overall survival. The regulation of Annexin A2 is of interest due to its potential as target for a more individualized cancer management.

OriginalsprogEngelsk
TidsskriftInternational Journal of Oncology
Vol/bind52
Udgave nummer1
Sider (fra-til)5-18
Antal sider14
ISSN1019-6439
DOI
StatusUdgivet - jan. 2018

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