Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Anhedonia and cognitive function in adults with MDD: results from the International Mood Disorders Collaborative Project

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Expert Consensus on Screening and Assessment of Cognition in Psychiatry

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Neuronal underpinnings of cognitive impairment and - improvement in mood disorders

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Incidence of suicidal behaviour and violent crime following antidepressant medication: a Danish cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Response to comment on Osler et al: misinterpretation of pre- and post differences invalidate the authors' conclusion

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  • Roger S McIntyre
  • Hanna O Woldeyohannes
  • Joanna K Soczynska
  • Nadia A Maruschak
  • Ida K Wium-Andersen
  • Maj Vinberg
  • Danielle S Cha
  • Yena Lee
  • Holly X Xiao
  • Laura Ashley Gallaugher
  • Roman M Dale
  • Mohammad T Alsuwaidan
  • Rodrigo B Mansur
  • David J Muzina
  • Andre F Carvalho
  • Jeanette M Jerrell
  • Sidney H Kennedy
Vis graf over relationer

BACKGROUND: Cognitive dysfunction is common in major depressive disorder (MDD) and a critical determinant of health outcome. Anhedonia is a criterion item toward the diagnosis of a major depressive episode (MDE) and a well-characterized domain in MDD. We sought to determine the extent to which variability in self-reported cognitive function correlates with anhedonia.

METHOD: A post hoc analysis was conducted using data from (N=369) participants with a Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR)-defined diagnosis of MDD who were enrolled in the International Mood Disorders Collaborative Project (IMDCP) between January 2008 and July 2013. The IMDCP is a collaborative research platform at the Mood Disorders Psychopharmacology Unit, University of Toronto, Toronto, Canada, and the Cleveland Clinic, Cleveland, Ohio. Measures of cognitive function, anhedonia, and depression severity were analyzed using linear regression equations.

RESULTS: A total of 369 adults with DSM-IV-TR-defined MDD were included in this analysis. Self-rated cognitive impairment [ie, as measured by the Adult ADHD Self-Report Scale (ASRS)] was significantly correlated with a proxy measure of anhedonia (r=0.131, p=0.012). Moreover, total depression symptom severity, as measured by the total Montgomery-Åsberg Depression Rating Scale (MADRS) score, was also significantly correlated with self-rated measures of cognitive dysfunction (r=0.147, p=0.005). The association between anhedonia and self-rated cognitive dysfunction remained significant after adjusting for illness severity (r=0.162, p=0.007).

CONCLUSIONS: These preliminary results provide empirical data for the testable hypothesis that anhedonia and self-reported cognitive function in MDD are correlated yet dissociable domains. The foregoing observation supports the hypothesis of overlapping yet discrete neurobiological substrates for these domains.

TidsskriftC N S Spectrums
Sider (fra-til)1-5
Antal sider5
StatusUdgivet - 30 dec. 2015

ID: 46170972