Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

ANGPTL4: a new mode in the regulation of intravascular lipolysis

Publikation: Bidrag til tidsskriftReviewpeer review

  1. Polygenic risk scores: how much do they add?

    Publikation: Bidrag til tidsskriftReviewpeer review

  2. Impact of metabolic dysfunction on cognition in humans

    Publikation: Bidrag til tidsskriftReviewpeer review

  3. Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  4. Remnant lipoproteins

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

Vis graf over relationer

PURPOSE OF REVIEW: Lipoprotein lipase (LPL) is the rate-limiting enzyme for intravascular processing of circulating triglyceride-rich lipoproteins (TRLs). One emerging strategy for therapeutic lowering of plasma triglyceride levels aims at increasing the longevity of LPL activity by attenuating its inhibition from angiopoietin-like proteins (ANGPTL) 3, 4 and 8. This mini-review focuses on recent insights into the molecular mechanisms underpinning the regulation of LPL activity in the intravascular unit by ANGPTLs with special emphasis on ANGPTL4.

RECENT FINDINGS: Our knowledge on the molecular interplays between LPL, its endothelial transporter GPIHBP1, and its inhibitor(s) ANGPTL4, ANGPTL3 and ANGPTL8 have advanced considerably in the last 2 years and provides an outlined on how these proteins regulate the activity and compartmentalization of LPL. A decisive determinant instigating this control is the inherent protein instability of LPL at normal body temperature, a property that is reciprocally impacted by the binding of GPIHBP1 and ANGPTLs. Additional layers in this complex LPL regulation is provided by the different modulation of ANGPTL4 and ANGPTL3 activities by ANGPTL8 and the inhibition of ANGPTL3/8 complexes by apolipoprotein A5 (APOA5).

SUMMARY: Posttranslational regulation of LPL activity in the intravascular space is essential for the differential partitioning of TRLs across tissues and their lipolytic processing in response to nutritional cues.

OriginalsprogEngelsk
TidsskriftCurrent Opinion in Lipidology
Vol/bind33
Udgave nummer2
Sider (fra-til)112-119
Antal sider8
ISSN0957-9672
DOI
StatusUdgivet - 1 apr. 2022

Bibliografisk note

Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

ID: 69920901