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Udgivet

Angiotensin-converting enzyme inhibitor-induced angioedema--a dangerous new epidemic

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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Vis graf over relationer

Angioedema is a sudden localised and often asymmetric swelling of the skin or mucous membranes caused by transient increased endothelial permeability causing plasma extravasation. In the last decades the incidence of severe angioedema involving the upper airways and even fatal outcome due to asphyxia has increased. This is mainly due to pharmaceuticals such as angiotensin converting enzyme-inhibitors, which are extensively used worldwide. Some aspects of the pathophysiology have been elucidated and the vasoactive molecule bradykinin is shown to be one of the main causative agents. The diagnosis is often delayed and traditional treatment usually ineffective. Complement C1 inhibitor concentrate and bradykinin receptor antagonists, normally used to treat patients with hereditary angioedema, have shown good results when used in patients with bradykinin-mediated angioedema. This review discusses the disease, prognosis and treatment options.

OriginalsprogEngelsk
TidsskriftActa Dermato-Venereologica
Vol/bind94
Udgave nummer3
Sider (fra-til)260-4
Antal sider5
ISSN0001-5555
DOI
StatusUdgivet - maj 2014
Eksternt udgivetJa

ID: 52553634