Angiotensin II type 1 receptor signalling regulates microRNA differentially in cardiac fibroblasts and myocytes

Pia Lindgren Jeppesen; Gitte Lund Christensen; Mikael Schneider; Anne Yaël Nossent; Hasse Brønnum Jensen; Ditte Caroline Andersen; Tilde Eskildsen; Steen Gammeltoft; Jakob Lerche Hansen; Søren Paludan Sheikh

doi:10.1111/j.1476-5381.2011.01375.x

Angiotensin II type 1 receptor signalling regulates microRNA differentially in cardiac fibroblasts and myocytes

Pia Lindgren Jeppesen
, Gitte Lund Christensen
, Mikael Schneider
, Anne Yaël Nossent
, Hasse Brønnum Jensen
, Ditte Caroline Andersen
, Tilde Eskildsen
, Steen Gammeltoft
, Jakob Lerche Hansen
, Søren Paludan Sheikh

Afdeling for Klinisk Biokemi

61 Citationer (Scopus)

Abstract

The angiotensin II type 1 receptor (AT(1)R) is a key regulator of blood pressure and cardiac contractility and is profoundly involved in development of cardiac disease. Since several microRNAs (miRNAs) have been implicated in cardiac disease, we determined whether miRNAs might be regulated by AT(1)R signals in a Gαq/11-dependent or -independent manner.

Originalsprog	Engelsk
Tidsskrift	British Journal of Pharmacology
Vol/bind	164
Udgave nummer	2
Sider (fra-til)	394-404
Antal sider	11
ISSN	0007-1188
DOI	https://doi.org/10.1111/j.1476-5381.2011.01375.x
Status	Udgivet - 2011

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10.1111/j.1476-5381.2011.01375.x

Citationsformater

Jeppesen, P. L., Christensen, G. L., Schneider, M., Nossent, A. Y., Jensen, H. B., Andersen, D. C., Eskildsen, T., Gammeltoft, S., Hansen, J. L., & Sheikh, S. P. (2011). Angiotensin II type 1 receptor signalling regulates microRNA differentially in cardiac fibroblasts and myocytes. British Journal of Pharmacology, 164(2), 394-404. https://doi.org/10.1111/j.1476-5381.2011.01375.x

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abstract = "The angiotensin II type 1 receptor (AT(1)R) is a key regulator of blood pressure and cardiac contractility and is profoundly involved in development of cardiac disease. Since several microRNAs (miRNAs) have been implicated in cardiac disease, we determined whether miRNAs might be regulated by AT(1)R signals in a Gαq/11-dependent or -independent manner.",

author = "Jeppesen, \{Pia Lindgren\} and Christensen, \{Gitte Lund\} and Mikael Schneider and Nossent, \{Anne Ya{\"e}l\} and Jensen, \{Hasse Br{\o}nnum\} and Andersen, \{Ditte Caroline\} and Tilde Eskildsen and Steen Gammeltoft and Hansen, \{Jakob Lerche\} and Sheikh, \{S{\o}ren Paludan\}",

note = "{\textcopyright} 2011 The Authors. British Journal of Pharmacology {\textcopyright} 2011 The British Pharmacological Society.",

year = "2011",

doi = "10.1111/j.1476-5381.2011.01375.x",

language = "English",

volume = "164",

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AU - Jeppesen, Pia Lindgren

AU - Christensen, Gitte Lund

AU - Schneider, Mikael

AU - Nossent, Anne Yaël

AU - Jensen, Hasse Brønnum

AU - Andersen, Ditte Caroline

AU - Eskildsen, Tilde

AU - Gammeltoft, Steen

AU - Hansen, Jakob Lerche

AU - Sheikh, Søren Paludan

PY - 2011

Y1 - 2011

N2 - The angiotensin II type 1 receptor (AT(1)R) is a key regulator of blood pressure and cardiac contractility and is profoundly involved in development of cardiac disease. Since several microRNAs (miRNAs) have been implicated in cardiac disease, we determined whether miRNAs might be regulated by AT(1)R signals in a Gαq/11-dependent or -independent manner.

AB - The angiotensin II type 1 receptor (AT(1)R) is a key regulator of blood pressure and cardiac contractility and is profoundly involved in development of cardiac disease. Since several microRNAs (miRNAs) have been implicated in cardiac disease, we determined whether miRNAs might be regulated by AT(1)R signals in a Gαq/11-dependent or -independent manner.

U2 - 10.1111/j.1476-5381.2011.01375.x

DO - 10.1111/j.1476-5381.2011.01375.x

M3 - Journal article

C2 - 21449976

SN - 0007-1188

VL - 164

SP - 394

EP - 404

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 2

ER -

Angiotensin II type 1 receptor signalling regulates microRNA differentially in cardiac fibroblasts and myocytes

Abstract

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