Angiotensin II-induced vasodilatation in cerebral arteries is mediated by endothelium-derived hyperpolarising factor

Angelica Wackenfors; Petter Vikman; Elisabeth Nilsson; Lars Edvinsson; Malin Malmsjö

doi:10.1016/j.ejphar.2005.11.064

Angiotensin II-induced vasodilatation in cerebral arteries is mediated by endothelium-derived hyperpolarising factor

Angelica Wackenfors, Petter Vikman, Elisabeth Nilsson, Lars Edvinsson, Malin Malmsjö

17 Citationer (Scopus)

Abstract

The angiotensin II-induced vasodilatation was evaluated in rat middle cerebral artery, especially regarding endothelium-derived hyperpolarising factor (EDHF), by use of a pressurised arteriograph. The angiotensin II dilatation was partly antagonised by inhibitors of nitric oxide synthase and cyclo-oxygenase. The remaining dilatation was inhibited by the potassium channel blockers, charybdotoxin and apamin, providing direct evidence that angiotensin II induces EDHF-mediated dilatation in cerebral arteries. The angiotensin II dilatation was blocked by the angiotensin AT1 and AT2 receptor blockers candesartan and PD 123319. Both angiotensin AT1 and AT2 receptors were detected on the endothelium by immunohistochemistry.

Originalsprog	Engelsk
Tidsskrift	European Journal of Pharmacology
Vol/bind	531
Udgave nummer	1-3
Sider (fra-til)	259-63
Antal sider	5
ISSN	0014-2999
DOI	https://doi.org/10.1016/j.ejphar.2005.11.064
Status	Udgivet - 15 feb. 2006
Udgivet eksternt	Ja

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10.1016/j.ejphar.2005.11.064

Citationsformater

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title = "Angiotensin II-induced vasodilatation in cerebral arteries is mediated by endothelium-derived hyperpolarising factor",

abstract = "The angiotensin II-induced vasodilatation was evaluated in rat middle cerebral artery, especially regarding endothelium-derived hyperpolarising factor (EDHF), by use of a pressurised arteriograph. The angiotensin II dilatation was partly antagonised by inhibitors of nitric oxide synthase and cyclo-oxygenase. The remaining dilatation was inhibited by the potassium channel blockers, charybdotoxin and apamin, providing direct evidence that angiotensin II induces EDHF-mediated dilatation in cerebral arteries. The angiotensin II dilatation was blocked by the angiotensin AT1 and AT2 receptor blockers candesartan and PD 123319. Both angiotensin AT1 and AT2 receptors were detected on the endothelium by immunohistochemistry.",

keywords = "Adenosine Triphosphate, Angiotensin II, Angiotensin II Type 1 Receptor Blockers, Animals, Anti-Inflammatory Agents, Non-Steroidal, Apamin, Benzimidazoles, Biological Factors, Cerebral Arteries, Charybdotoxin, Dose-Response Relationship, Drug, Endothelium, Vascular, Enzyme Inhibitors, Imidazoles, In Vitro Techniques, Indomethacin, Male, Neurotoxins, Nitric Oxide Synthase, Nitroarginine, Pyridines, Rats, Rats, Sprague-Dawley, Serotonin, Tetrazoles, Vasoconstriction, Vasoconstrictor Agents",

author = "Angelica Wackenfors and Petter Vikman and Elisabeth Nilsson and Lars Edvinsson and Malin Malmsj{\"o}",

year = "2006",

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doi = "10.1016/j.ejphar.2005.11.064",

language = "English",

volume = "531",

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TY - JOUR

T1 - Angiotensin II-induced vasodilatation in cerebral arteries is mediated by endothelium-derived hyperpolarising factor

AU - Wackenfors, Angelica

AU - Vikman, Petter

AU - Nilsson, Elisabeth

AU - Edvinsson, Lars

AU - Malmsjö, Malin

PY - 2006/2/15

Y1 - 2006/2/15

N2 - The angiotensin II-induced vasodilatation was evaluated in rat middle cerebral artery, especially regarding endothelium-derived hyperpolarising factor (EDHF), by use of a pressurised arteriograph. The angiotensin II dilatation was partly antagonised by inhibitors of nitric oxide synthase and cyclo-oxygenase. The remaining dilatation was inhibited by the potassium channel blockers, charybdotoxin and apamin, providing direct evidence that angiotensin II induces EDHF-mediated dilatation in cerebral arteries. The angiotensin II dilatation was blocked by the angiotensin AT1 and AT2 receptor blockers candesartan and PD 123319. Both angiotensin AT1 and AT2 receptors were detected on the endothelium by immunohistochemistry.

AB - The angiotensin II-induced vasodilatation was evaluated in rat middle cerebral artery, especially regarding endothelium-derived hyperpolarising factor (EDHF), by use of a pressurised arteriograph. The angiotensin II dilatation was partly antagonised by inhibitors of nitric oxide synthase and cyclo-oxygenase. The remaining dilatation was inhibited by the potassium channel blockers, charybdotoxin and apamin, providing direct evidence that angiotensin II induces EDHF-mediated dilatation in cerebral arteries. The angiotensin II dilatation was blocked by the angiotensin AT1 and AT2 receptor blockers candesartan and PD 123319. Both angiotensin AT1 and AT2 receptors were detected on the endothelium by immunohistochemistry.

KW - Adenosine Triphosphate

KW - Angiotensin II

KW - Angiotensin II Type 1 Receptor Blockers

KW - Animals

KW - Anti-Inflammatory Agents, Non-Steroidal

KW - Apamin

KW - Benzimidazoles

KW - Biological Factors

KW - Cerebral Arteries

KW - Charybdotoxin

KW - Dose-Response Relationship, Drug

KW - Endothelium, Vascular

KW - Enzyme Inhibitors

KW - Imidazoles

KW - In Vitro Techniques

KW - Indomethacin

KW - Male

KW - Neurotoxins

KW - Nitric Oxide Synthase

KW - Nitroarginine

KW - Pyridines

KW - Rats

KW - Rats, Sprague-Dawley

KW - Serotonin

KW - Tetrazoles

KW - Vasoconstriction

KW - Vasoconstrictor Agents

U2 - 10.1016/j.ejphar.2005.11.064

DO - 10.1016/j.ejphar.2005.11.064

M3 - Journal article

C2 - 16410000

SN - 0014-2999

VL - 531

SP - 259

EP - 263

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1-3

ER -

Angiotensin II-induced vasodilatation in cerebral arteries is mediated by endothelium-derived hyperpolarising factor

Abstract

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