Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Ashley H Beecham; Nikolaos A Patsopoulos; Dionysia K Xifara; Mary F Davis; Anu Kemppinen; Chris Cotsapas; Tejas S Shah; Chris Spencer; David Booth; An Goris; Annette Oturai; Janna Saarela; Bertrand Fontaine; Bernhard Hemmer; Claes Martin; Frauke Zipp; Sandra D'Alfonso; Filippo Martinelli-Boneschi; Bruce Taylor; Hanne F Harbo; Ingrid Kockum; Jan Hillert; Tomas Olsson; Maria Ban; Jorge R Oksenberg; Rogier Hintzen; Lisa F Barcellos; Cristina Agliardi; Lars Alfredsson; Mehdi Alizadeh; Carl Anderson; Robert Andrews; Helle Bach Søndergaard; Amie Baker; Gavin Band; Sergio E Baranzini; Nadia Barizzone; Jeffrey Barrett; Céline Bellenguez; Laura Bergamaschi; Luisa Bernardinelli; Achim Berthele; Viola Biberacher; Thomas Binder; Hannah Blackburn; Izaura L Bomfim; Paola Brambilla; Simon Broadley; Finn Sellebjerg; Per Soelberg Sorensen; International Multiple Sclerosis Genetics Consortium (IMSGC)

doi:10.1038/ng.2770

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Ashley H Beecham, Nikolaos A Patsopoulos, Dionysia K Xifara, Mary F Davis, Anu Kemppinen, Chris Cotsapas, Tejas S Shah, Chris Spencer, David Booth, An Goris, Annette Oturai, Janna Saarela, Bertrand Fontaine, Bernhard Hemmer, Claes Martin, Frauke Zipp, Sandra D'Alfonso, Filippo Martinelli-Boneschi, Bruce Taylor, Hanne F HarboIngrid Kockum, Jan Hillert, Tomas Olsson, Maria Ban, Jorge R Oksenberg, Rogier Hintzen, Lisa F Barcellos, Cristina Agliardi, Lars Alfredsson, Mehdi Alizadeh, Carl Anderson, Robert Andrews, Helle Bach Søndergaard, Amie Baker, Gavin Band, Sergio E Baranzini, Nadia Barizzone, Jeffrey Barrett, Céline Bellenguez, Laura Bergamaschi, Luisa Bernardinelli, Achim Berthele, Viola Biberacher, Thomas Binder, Hannah Blackburn, Izaura L Bomfim, Paola Brambilla, Simon Broadley, Finn Sellebjerg, Per Soelberg Sorensen, International Multiple Sclerosis Genetics Consortium (IMSGC)

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1021 Citationer (Scopus)

Abstract

Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P

Originalsprog	Engelsk
Tidsskrift	Nature Genetics
Vol/bind	45
Udgave nummer	11
Sider (fra-til)	1353-60
Antal sider	8
ISSN	1061-4036
DOI	https://doi.org/10.1038/ng.2770
Status	Udgivet - nov. 2013

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10.1038/ng.2770

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Beecham, A. H., Patsopoulos, N. A., Xifara, D. K., Davis, M. F., Kemppinen, A., Cotsapas, C., Shah, T. S., Spencer, C., Booth, D., Goris, A., Oturai, A., Saarela, J., Fontaine, B., Hemmer, B., Martin, C., Zipp, F., D'Alfonso, S., Martinelli-Boneschi, F., Taylor, B., ... International Multiple Sclerosis Genetics Consortium (IMSGC) (2013). Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nature Genetics, 45(11), 1353-60. https://doi.org/10.1038/ng.2770

Beecham, AH, Patsopoulos, NA, Xifara, DK, Davis, MF, Kemppinen, A, Cotsapas, C, Shah, TS, Spencer, C, Booth, D, Goris, A, Oturai, A, Saarela, J, Fontaine, B, Hemmer, B, Martin, C, Zipp, F, D'Alfonso, S, Martinelli-Boneschi, F, Taylor, B, Harbo, HF, Kockum, I, Hillert, J, Olsson, T, Ban, M, Oksenberg, JR, Hintzen, R, Barcellos, LF, Agliardi, C, Alfredsson, L, Alizadeh, M, Anderson, C, Andrews, R, Søndergaard, HB, Baker, A, Band, G, Baranzini, SE, Barizzone, N, Barrett, J, Bellenguez, C, Bergamaschi, L, Bernardinelli, L, Berthele, A, Biberacher, V, Binder, T, Blackburn, H, Bomfim, IL, Brambilla, P, Broadley, S, Sellebjerg, F , Sorensen, PS & International Multiple Sclerosis Genetics Consortium (IMSGC) 2013, 'Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis', Nature Genetics, bind 45, nr. 11, s. 1353-60. https://doi.org/10.1038/ng.2770

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title = "Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis",

abstract = "Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P ",

keywords = "Chromosome Mapping, European Continental Ancestry Group, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotype, Humans, Multiple Sclerosis, Polymorphism, Single Nucleotide",

author = "Beecham, {Ashley H} and Patsopoulos, {Nikolaos A} and Xifara, {Dionysia K} and Davis, {Mary F} and Anu Kemppinen and Chris Cotsapas and Shah, {Tejas S} and Chris Spencer and David Booth and An Goris and Annette Oturai and Janna Saarela and Bertrand Fontaine and Bernhard Hemmer and Claes Martin and Frauke Zipp and Sandra D'Alfonso and Filippo Martinelli-Boneschi and Bruce Taylor and Harbo, {Hanne F} and Ingrid Kockum and Jan Hillert and Tomas Olsson and Maria Ban and Oksenberg, {Jorge R} and Rogier Hintzen and Barcellos, {Lisa F} and Cristina Agliardi and Lars Alfredsson and Mehdi Alizadeh and Carl Anderson and Robert Andrews and S{\o}ndergaard, {Helle Bach} and Amie Baker and Gavin Band and Baranzini, {Sergio E} and Nadia Barizzone and Jeffrey Barrett and C{\'e}line Bellenguez and Laura Bergamaschi and Luisa Bernardinelli and Achim Berthele and Viola Biberacher and Thomas Binder and Hannah Blackburn and Bomfim, {Izaura L} and Paola Brambilla and Simon Broadley and Finn Sellebjerg and Sorensen, {Per Soelberg} and {International Multiple Sclerosis Genetics Consortium (IMSGC)}",

year = "2013",

month = nov,

doi = "10.1038/ng.2770",

language = "English",

volume = "45",

pages = "1353--60",

journal = "Nature Genetics",

issn = "1061-4036",

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T1 - Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

AU - Beecham, Ashley H

AU - Patsopoulos, Nikolaos A

AU - Xifara, Dionysia K

AU - Davis, Mary F

AU - Kemppinen, Anu

AU - Cotsapas, Chris

AU - Shah, Tejas S

AU - Spencer, Chris

AU - Booth, David

AU - Goris, An

AU - Oturai, Annette

AU - Saarela, Janna

AU - Fontaine, Bertrand

AU - Hemmer, Bernhard

AU - Martin, Claes

AU - Zipp, Frauke

AU - D'Alfonso, Sandra

AU - Martinelli-Boneschi, Filippo

AU - Taylor, Bruce

AU - Harbo, Hanne F

AU - Kockum, Ingrid

AU - Hillert, Jan

AU - Olsson, Tomas

AU - Ban, Maria

AU - Oksenberg, Jorge R

AU - Hintzen, Rogier

AU - Barcellos, Lisa F

AU - Agliardi, Cristina

AU - Alfredsson, Lars

AU - Alizadeh, Mehdi

AU - Anderson, Carl

AU - Andrews, Robert

AU - Søndergaard, Helle Bach

AU - Baker, Amie

AU - Band, Gavin

AU - Baranzini, Sergio E

AU - Barizzone, Nadia

AU - Barrett, Jeffrey

AU - Bellenguez, Céline

AU - Bergamaschi, Laura

AU - Bernardinelli, Luisa

AU - Berthele, Achim

AU - Biberacher, Viola

AU - Binder, Thomas

AU - Blackburn, Hannah

AU - Bomfim, Izaura L

AU - Brambilla, Paola

AU - Broadley, Simon

AU - Sellebjerg, Finn

AU - Sorensen, Per Soelberg

AU - International Multiple Sclerosis Genetics Consortium (IMSGC)

PY - 2013/11

Y1 - 2013/11

N2 - Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P

AB - Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P

KW - Chromosome Mapping

KW - European Continental Ancestry Group

KW - Gene Frequency

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genetic Variation

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Multiple Sclerosis

KW - Polymorphism, Single Nucleotide

U2 - 10.1038/ng.2770

DO - 10.1038/ng.2770

M3 - Journal article

C2 - 24076602

VL - 45

SP - 1353

EP - 1360

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 11

ER -

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Abstract

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