TY - JOUR
T1 - Analysis of DNA repair gene polymorphisms and survival in low-grade and anaplastic gliomas
AU - Berntsson, Shala Ghaderi
AU - Wibom, Carl
AU - Sjöström, Sara
AU - Henriksson, Roger
AU - Brännström, Thomas
AU - Broholm, Helle
AU - Johansson, Christoffer
AU - Fleming, Sarah J
AU - McKinney, Patricia A
AU - Bethke, Lara
AU - Houlston, Richard
AU - Smits, Anja
AU - Andersson, Ulrika
AU - Melin, Beatrice S
PY - 2011
Y1 - 2011
N2 - The purpose of this study was to explore the variation in DNA repair genes in adults with WHO grade II and III gliomas and their relationship to patient survival. We analysed a total of 1,458 tagging single-nucleotide polymorphisms (SNPs) that were selected to cover DNA repair genes, in 81 grade II and grade III gliomas samples, collected in Sweden and Denmark. The statistically significant genetic variants from the first dataset (P <0.05) were taken forward for confirmation in a second dataset of 72 grade II and III gliomas from northern UK. In this dataset, eight gene variants mapping to five different DNA repair genes (ATM, NEIL1, NEIL2, ERCC6 and RPA4) which were associated with survival. Finally, these eight genetic variants were adjusted for treatment, malignancy grade, patient age and gender, leaving one variant, rs4253079, mapped to ERCC6, with a significant association to survival (OR 0.184, 95% CI 0.054-0.63, P = 0.007). We suggest a possible novel association between rs4253079 and survival in this group of patients with low-grade and anaplastic gliomas that needs confirmation in larger datasets.
AB - The purpose of this study was to explore the variation in DNA repair genes in adults with WHO grade II and III gliomas and their relationship to patient survival. We analysed a total of 1,458 tagging single-nucleotide polymorphisms (SNPs) that were selected to cover DNA repair genes, in 81 grade II and grade III gliomas samples, collected in Sweden and Denmark. The statistically significant genetic variants from the first dataset (P <0.05) were taken forward for confirmation in a second dataset of 72 grade II and III gliomas from northern UK. In this dataset, eight gene variants mapping to five different DNA repair genes (ATM, NEIL1, NEIL2, ERCC6 and RPA4) which were associated with survival. Finally, these eight genetic variants were adjusted for treatment, malignancy grade, patient age and gender, leaving one variant, rs4253079, mapped to ERCC6, with a significant association to survival (OR 0.184, 95% CI 0.054-0.63, P = 0.007). We suggest a possible novel association between rs4253079 and survival in this group of patients with low-grade and anaplastic gliomas that needs confirmation in larger datasets.
U2 - 10.1007/s11060-011-0614-5
DO - 10.1007/s11060-011-0614-5
M3 - Journal article
C2 - 21643987
SN - 0167-594X
VL - 105
SP - 531
EP - 538
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
IS - 3
ER -