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Analgesic use in adolescents with patellofemoral pain or Osgood-Schlatter Disease: a secondary cross-sectional analysis of 323 subjects

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Andreucci, Alessandro ; Roos, Ewa M ; Rasmussen, Sten ; Olesen, Jens L ; Hölmich, Per ; Thorborg, Kristian ; Rathleff, Michael Skovdal. / Analgesic use in adolescents with patellofemoral pain or Osgood-Schlatter Disease : a secondary cross-sectional analysis of 323 subjects. I: Scandinavian Journal of Pain. 2022 ; Bind 22, Nr. 3. s. 543-551.

Bibtex

@article{812663148c114f2c901365e3ded6ba76,
title = "Analgesic use in adolescents with patellofemoral pain or Osgood-Schlatter Disease: a secondary cross-sectional analysis of 323 subjects",
abstract = "The prevalence of pain medication use for adolescent knee pain and factors associated with use are not well understood. This study aimed to determine the self-reported use of pain medication for knee pain and identify factors associated with use in adolescents (age 10-19) with longstanding knee symptoms. In this exploratory cross-sectional study, we performed a secondary analysis of data previously collected in 323 adolescents with longstanding knee pain. Factors associated with pain medication use were assessed using multivariable logistic regressions. Analyses were repeated with stratification by age, sex, sport participation frequency, knee pain duration, and knee pain intensity. Among 323 adolescents (mean age 14.4 ± 2.5, 73% female), 84% had patellofemoral pain, (peri- or retro-patellar pain during loaded bending of the knee) and 16% had Osgood-Schlatter Disease (apophysitis with swelling and localized pain at the tibial tuberosity). Twenty-one percent (95% CI 16-25%) of adolescents reported pain medication use for their knee pain, with no difference in usage between those ≤ vs. > 15 years of age (21%, 95% CI 16-27% vs. 20%, 95% CI 13-29%). Adolescents with patellofemoral pain reported greater usage than their counterparts with Osgood-Schlatter Disease (22%, 95% CI 17-28% vs. 12%, 95% CI 4.5-24.3%). The most consistent factor associated with use was knee-related symptoms, observed in both the overall (OR 0.97, 95% CI 0.94-0.99) and stratified analyses (ORs ranged from 0.89 to 0.96). Approximately one in five adolescents with longstanding knee pain reported pain medication use, particularly in adolescents with patellofemoral pain. Knee-related symptoms most consistently associated with the use of pain medications in this population. Future longitudinal studies with data collected at multiple time-points are needed to validate these findings. Self-reported pain medication use is common in adolescents with longstanding knee pain, even though whether pharmacological therapy is the best pain management option at this young age is debatable. Reliance on pain medication at an early age could potentially hamper the development of healthy pain coping strategies and increase the risk of dependence and misuse later in life. Future studies should assess the safety, efficacy, and risks of long-term use of pain medications for adolescent knee pain.",
keywords = "Adolescent, analgesics, cross-sectional studies, knee joint, pain management, patellofemoral pain syndrome, Osteochondrosis, Cross-Sectional Studies, Humans, Male, Young Adult, Pain, Adult, Female, Analgesics/therapeutic use, Child, Patellofemoral Pain Syndrome/drug therapy",
author = "Alessandro Andreucci and Roos, {Ewa M} and Sten Rasmussen and Olesen, {Jens L} and Per H{\"o}lmich and Kristian Thorborg and Rathleff, {Michael Skovdal}",
note = "{\textcopyright} 2021 Walter de Gruyter GmbH, Berlin/Boston.",
year = "2022",
month = jul,
day = "26",
doi = "10.1515/sjpain-2021-0121",
language = "English",
volume = "22",
pages = "543--551",
journal = "Scandinavian Journal of Pain",
issn = "1877-8860",
publisher = "Elsevier Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Analgesic use in adolescents with patellofemoral pain or Osgood-Schlatter Disease

T2 - a secondary cross-sectional analysis of 323 subjects

AU - Andreucci, Alessandro

AU - Roos, Ewa M

AU - Rasmussen, Sten

AU - Olesen, Jens L

AU - Hölmich, Per

AU - Thorborg, Kristian

AU - Rathleff, Michael Skovdal

N1 - © 2021 Walter de Gruyter GmbH, Berlin/Boston.

PY - 2022/7/26

Y1 - 2022/7/26

N2 - The prevalence of pain medication use for adolescent knee pain and factors associated with use are not well understood. This study aimed to determine the self-reported use of pain medication for knee pain and identify factors associated with use in adolescents (age 10-19) with longstanding knee symptoms. In this exploratory cross-sectional study, we performed a secondary analysis of data previously collected in 323 adolescents with longstanding knee pain. Factors associated with pain medication use were assessed using multivariable logistic regressions. Analyses were repeated with stratification by age, sex, sport participation frequency, knee pain duration, and knee pain intensity. Among 323 adolescents (mean age 14.4 ± 2.5, 73% female), 84% had patellofemoral pain, (peri- or retro-patellar pain during loaded bending of the knee) and 16% had Osgood-Schlatter Disease (apophysitis with swelling and localized pain at the tibial tuberosity). Twenty-one percent (95% CI 16-25%) of adolescents reported pain medication use for their knee pain, with no difference in usage between those ≤ vs. > 15 years of age (21%, 95% CI 16-27% vs. 20%, 95% CI 13-29%). Adolescents with patellofemoral pain reported greater usage than their counterparts with Osgood-Schlatter Disease (22%, 95% CI 17-28% vs. 12%, 95% CI 4.5-24.3%). The most consistent factor associated with use was knee-related symptoms, observed in both the overall (OR 0.97, 95% CI 0.94-0.99) and stratified analyses (ORs ranged from 0.89 to 0.96). Approximately one in five adolescents with longstanding knee pain reported pain medication use, particularly in adolescents with patellofemoral pain. Knee-related symptoms most consistently associated with the use of pain medications in this population. Future longitudinal studies with data collected at multiple time-points are needed to validate these findings. Self-reported pain medication use is common in adolescents with longstanding knee pain, even though whether pharmacological therapy is the best pain management option at this young age is debatable. Reliance on pain medication at an early age could potentially hamper the development of healthy pain coping strategies and increase the risk of dependence and misuse later in life. Future studies should assess the safety, efficacy, and risks of long-term use of pain medications for adolescent knee pain.

AB - The prevalence of pain medication use for adolescent knee pain and factors associated with use are not well understood. This study aimed to determine the self-reported use of pain medication for knee pain and identify factors associated with use in adolescents (age 10-19) with longstanding knee symptoms. In this exploratory cross-sectional study, we performed a secondary analysis of data previously collected in 323 adolescents with longstanding knee pain. Factors associated with pain medication use were assessed using multivariable logistic regressions. Analyses were repeated with stratification by age, sex, sport participation frequency, knee pain duration, and knee pain intensity. Among 323 adolescents (mean age 14.4 ± 2.5, 73% female), 84% had patellofemoral pain, (peri- or retro-patellar pain during loaded bending of the knee) and 16% had Osgood-Schlatter Disease (apophysitis with swelling and localized pain at the tibial tuberosity). Twenty-one percent (95% CI 16-25%) of adolescents reported pain medication use for their knee pain, with no difference in usage between those ≤ vs. > 15 years of age (21%, 95% CI 16-27% vs. 20%, 95% CI 13-29%). Adolescents with patellofemoral pain reported greater usage than their counterparts with Osgood-Schlatter Disease (22%, 95% CI 17-28% vs. 12%, 95% CI 4.5-24.3%). The most consistent factor associated with use was knee-related symptoms, observed in both the overall (OR 0.97, 95% CI 0.94-0.99) and stratified analyses (ORs ranged from 0.89 to 0.96). Approximately one in five adolescents with longstanding knee pain reported pain medication use, particularly in adolescents with patellofemoral pain. Knee-related symptoms most consistently associated with the use of pain medications in this population. Future longitudinal studies with data collected at multiple time-points are needed to validate these findings. Self-reported pain medication use is common in adolescents with longstanding knee pain, even though whether pharmacological therapy is the best pain management option at this young age is debatable. Reliance on pain medication at an early age could potentially hamper the development of healthy pain coping strategies and increase the risk of dependence and misuse later in life. Future studies should assess the safety, efficacy, and risks of long-term use of pain medications for adolescent knee pain.

KW - Adolescent

KW - analgesics

KW - cross-sectional studies

KW - knee joint

KW - pain management

KW - patellofemoral pain syndrome

KW - Osteochondrosis

KW - Cross-Sectional Studies

KW - Humans

KW - Male

KW - Young Adult

KW - Pain

KW - Adult

KW - Female

KW - Analgesics/therapeutic use

KW - Child

KW - Patellofemoral Pain Syndrome/drug therapy

UR - http://www.scopus.com/inward/record.url?scp=85120942774&partnerID=8YFLogxK

U2 - 10.1515/sjpain-2021-0121

DO - 10.1515/sjpain-2021-0121

M3 - Journal article

C2 - 34860477

VL - 22

SP - 543

EP - 551

JO - Scandinavian Journal of Pain

JF - Scandinavian Journal of Pain

SN - 1877-8860

IS - 3

M1 - 0121

ER -

ID: 69545535