Anal carcinoma - Survival and recurrence in a large cohort of patients treated according to Nordic guidelines

Otilia Leon; Marianne Guren; Oskar Hagberg; Bengt Glimelius; Olav Dahl; Hanne Havsteen; Gisela Naucler; Christer Svensson; Kjell Magne Tveit; Anders Jakobsen; Per Pfeiffer; Eva Wanderås; Tor Ekman; Birgitta Lindh; Lise Balteskard; Gunilla Frykholm; Anders Johnsson

doi:10.1016/j.radonc.2014.10.002

Anal carcinoma - Survival and recurrence in a large cohort of patients treated according to Nordic guidelines

Otilia Leon, Marianne Guren, Oskar Hagberg, Bengt Glimelius, Olav Dahl, Hanne Havsteen, Gisela Naucler, Christer Svensson, Kjell Magne Tveit, Anders Jakobsen, Per Pfeiffer, Eva Wanderås, Tor Ekman, Birgitta Lindh, Lise Balteskard, Gunilla Frykholm, Anders Johnsson

Kræftbehandling

51 Citationer (Scopus)

Abstract

OBJECTIVE: To evaluate treatment outcome in a large population-based cohort of patients with anal cancer treated according to Nordic guidelines.

MATERIAL: Clinical data were collected on 1266 patients with anal squamous cell carcinoma diagnosed from 2000 to 2007 in Sweden, Norway and Denmark. 886 of the patients received radiotherapy 54-64Gy with or without chemotherapy (5-fluorouracil plus cisplatin or mitomycin) according to different protocols, stratified by tumor stage.

RESULTS: High age, male gender, large primary tumor, lymph node metastases, distant metastases, poor performance status, and non-inclusion into a protocol were all independent factors associated with worse outcome. Among patients treated according to any of the protocols, the 3-year recurrence-free survival ranged from 63% to 76%, with locoregional recurrences in 17% and distant metastases in 11% of patients. The highest rate of inguinal recurrence (11%) was seen in patients with small primary tumors, treated without inguinal irradiation.

CONCLUSIONS: Good treatment efficacy was obtained with Nordic, widely implemented, guidelines for treatment of anal cancer. Inguinal prophylactic irradiation should be recommended also for small primary tumors.

Originalsprog	Engelsk
Tidsskrift	Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Vol/bind	113
Udgave nummer	3
Sider (fra-til)	352-8
Antal sider	7
ISSN	0167-8140
DOI	https://doi.org/10.1016/j.radonc.2014.10.002
Status	Udgivet - dec. 2014

Adgang til dokumentet

10.1016/j.radonc.2014.10.002

Citationsformater

Leon, O., Guren, M., Hagberg, O., Glimelius, B., Dahl, O., Havsteen, H., Naucler, G., Svensson, C., Tveit, K. M., Jakobsen, A., Pfeiffer, P., Wanderås, E., Ekman, T., Lindh, B., Balteskard, L., Frykholm, G., & Johnsson, A. (2014). Anal carcinoma - Survival and recurrence in a large cohort of patients treated according to Nordic guidelines. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 113(3), 352-8. https://doi.org/10.1016/j.radonc.2014.10.002

Anal carcinoma - Survival and recurrence in a large cohort of patients treated according to Nordic guidelines. / Leon, Otilia; Guren, Marianne; Hagberg, Oskar et al.
I: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, Bind 113, Nr. 3, 12.2014, s. 352-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Leon, O, Guren, M, Hagberg, O, Glimelius, B, Dahl, O, Havsteen, H, Naucler, G, Svensson, C, Tveit, KM, Jakobsen, A, Pfeiffer, P, Wanderås, E, Ekman, T, Lindh, B, Balteskard, L, Frykholm, G & Johnsson, A 2014, 'Anal carcinoma - Survival and recurrence in a large cohort of patients treated according to Nordic guidelines', Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, bind 113, nr. 3, s. 352-8. https://doi.org/10.1016/j.radonc.2014.10.002

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title = "Anal carcinoma - Survival and recurrence in a large cohort of patients treated according to Nordic guidelines",

abstract = "OBJECTIVE: To evaluate treatment outcome in a large population-based cohort of patients with anal cancer treated according to Nordic guidelines.MATERIAL: Clinical data were collected on 1266 patients with anal squamous cell carcinoma diagnosed from 2000 to 2007 in Sweden, Norway and Denmark. 886 of the patients received radiotherapy 54-64Gy with or without chemotherapy (5-fluorouracil plus cisplatin or mitomycin) according to different protocols, stratified by tumor stage.RESULTS: High age, male gender, large primary tumor, lymph node metastases, distant metastases, poor performance status, and non-inclusion into a protocol were all independent factors associated with worse outcome. Among patients treated according to any of the protocols, the 3-year recurrence-free survival ranged from 63% to 76%, with locoregional recurrences in 17% and distant metastases in 11% of patients. The highest rate of inguinal recurrence (11%) was seen in patients with small primary tumors, treated without inguinal irradiation.CONCLUSIONS: Good treatment efficacy was obtained with Nordic, widely implemented, guidelines for treatment of anal cancer. Inguinal prophylactic irradiation should be recommended also for small primary tumors.",

author = "Otilia Leon and Marianne Guren and Oskar Hagberg and Bengt Glimelius and Olav Dahl and Hanne Havsteen and Gisela Naucler and Christer Svensson and Tveit, {Kjell Magne} and Anders Jakobsen and Per Pfeiffer and Eva Wander{\aa}s and Tor Ekman and Birgitta Lindh and Lise Balteskard and Gunilla Frykholm and Anders Johnsson",

year = "2014",

month = dec,

doi = "10.1016/j.radonc.2014.10.002",

language = "English",

volume = "113",

pages = "352--8",

journal = "Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology",

issn = "0167-8140",

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TY - JOUR

T1 - Anal carcinoma - Survival and recurrence in a large cohort of patients treated according to Nordic guidelines

AU - Leon, Otilia

AU - Guren, Marianne

AU - Hagberg, Oskar

AU - Glimelius, Bengt

AU - Dahl, Olav

AU - Havsteen, Hanne

AU - Naucler, Gisela

AU - Svensson, Christer

AU - Tveit, Kjell Magne

AU - Jakobsen, Anders

AU - Pfeiffer, Per

AU - Wanderås, Eva

AU - Ekman, Tor

AU - Lindh, Birgitta

AU - Balteskard, Lise

AU - Frykholm, Gunilla

AU - Johnsson, Anders

PY - 2014/12

Y1 - 2014/12

N2 - OBJECTIVE: To evaluate treatment outcome in a large population-based cohort of patients with anal cancer treated according to Nordic guidelines.MATERIAL: Clinical data were collected on 1266 patients with anal squamous cell carcinoma diagnosed from 2000 to 2007 in Sweden, Norway and Denmark. 886 of the patients received radiotherapy 54-64Gy with or without chemotherapy (5-fluorouracil plus cisplatin or mitomycin) according to different protocols, stratified by tumor stage.RESULTS: High age, male gender, large primary tumor, lymph node metastases, distant metastases, poor performance status, and non-inclusion into a protocol were all independent factors associated with worse outcome. Among patients treated according to any of the protocols, the 3-year recurrence-free survival ranged from 63% to 76%, with locoregional recurrences in 17% and distant metastases in 11% of patients. The highest rate of inguinal recurrence (11%) was seen in patients with small primary tumors, treated without inguinal irradiation.CONCLUSIONS: Good treatment efficacy was obtained with Nordic, widely implemented, guidelines for treatment of anal cancer. Inguinal prophylactic irradiation should be recommended also for small primary tumors.

AB - OBJECTIVE: To evaluate treatment outcome in a large population-based cohort of patients with anal cancer treated according to Nordic guidelines.MATERIAL: Clinical data were collected on 1266 patients with anal squamous cell carcinoma diagnosed from 2000 to 2007 in Sweden, Norway and Denmark. 886 of the patients received radiotherapy 54-64Gy with or without chemotherapy (5-fluorouracil plus cisplatin or mitomycin) according to different protocols, stratified by tumor stage.RESULTS: High age, male gender, large primary tumor, lymph node metastases, distant metastases, poor performance status, and non-inclusion into a protocol were all independent factors associated with worse outcome. Among patients treated according to any of the protocols, the 3-year recurrence-free survival ranged from 63% to 76%, with locoregional recurrences in 17% and distant metastases in 11% of patients. The highest rate of inguinal recurrence (11%) was seen in patients with small primary tumors, treated without inguinal irradiation.CONCLUSIONS: Good treatment efficacy was obtained with Nordic, widely implemented, guidelines for treatment of anal cancer. Inguinal prophylactic irradiation should be recommended also for small primary tumors.

U2 - 10.1016/j.radonc.2014.10.002

DO - 10.1016/j.radonc.2014.10.002

M3 - Journal article

C2 - 25499203

SN - 0167-8140

VL - 113

SP - 352

EP - 358

JO - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

JF - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

IS - 3

ER -

Anal carcinoma - Survival and recurrence in a large cohort of patients treated according to Nordic guidelines

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