Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Anal carcinoma - Survival and recurrence in a large cohort of patients treated according to Nordic guidelines

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Diffusion MRI outlined viable tumour volume beats GTV in intra-treatment stratification of outcome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Diabetes increases the risk of serious adverse events after re-irradiation of the spine

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Influence of volumetric modulated arc therapy and FET-PET scanning on treatment outcomes for glioblastoma patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Tumour-infiltrating lymphocyte scores effectively stratify outcomes over and above p16 post chemo-radiotherapy in anal cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Gestational trophoblastic diseases - clinical guidelines for diagnosis, treatment, follow-up, and counselling

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. KRAS and BRAF mutations in anal carcinoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Otilia Leon
  • Marianne Guren
  • Oskar Hagberg
  • Bengt Glimelius
  • Olav Dahl
  • Hanne Havsteen
  • Gisela Naucler
  • Christer Svensson
  • Kjell Magne Tveit
  • Anders Jakobsen
  • Per Pfeiffer
  • Eva Wanderås
  • Tor Ekman
  • Birgitta Lindh
  • Lise Balteskard
  • Gunilla Frykholm
  • Anders Johnsson
Vis graf over relationer

OBJECTIVE: To evaluate treatment outcome in a large population-based cohort of patients with anal cancer treated according to Nordic guidelines.

MATERIAL: Clinical data were collected on 1266 patients with anal squamous cell carcinoma diagnosed from 2000 to 2007 in Sweden, Norway and Denmark. 886 of the patients received radiotherapy 54-64Gy with or without chemotherapy (5-fluorouracil plus cisplatin or mitomycin) according to different protocols, stratified by tumor stage.

RESULTS: High age, male gender, large primary tumor, lymph node metastases, distant metastases, poor performance status, and non-inclusion into a protocol were all independent factors associated with worse outcome. Among patients treated according to any of the protocols, the 3-year recurrence-free survival ranged from 63% to 76%, with locoregional recurrences in 17% and distant metastases in 11% of patients. The highest rate of inguinal recurrence (11%) was seen in patients with small primary tumors, treated without inguinal irradiation.

CONCLUSIONS: Good treatment efficacy was obtained with Nordic, widely implemented, guidelines for treatment of anal cancer. Inguinal prophylactic irradiation should be recommended also for small primary tumors.

OriginalsprogEngelsk
TidsskriftRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Vol/bind113
Udgave nummer3
Sider (fra-til)352-8
Antal sider7
ISSN0167-8140
DOI
StatusUdgivet - dec. 2014

ID: 44833395