Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

An fMRI-compatible system for targeted electrical stimulation

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  1. Double diffusion encoding and applications for biomedical imaging

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  2. Automatic delineation of brain regions on MRI and PET images from the pig

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  3. Comparison of Analytical Methods of Brain [(18)F]FDG-PET after Severe Traumatic Brain Injury

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  1. Trajectory of aberrant reward processing in patients with bipolar disorder - A longitudinal fMRI study

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  2. Automated ictal EEG source imaging: A retrospective, blinded clinical validation study

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  3. Brain serotonin transporter is associated with cognitive-affective biases in healthy individuals

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  4. A deep learning-based whole-body solution for PET/MRI attenuation correction

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  5. Acute and long-term effects of psilocybin on energy balance and feeding behavior in mice

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

Vis graf over relationer

BACKGROUND: Neuromodulation is a rapidly expanding therapeutic option considered within neuropsychiatry, pain and rehabilitation therapy. Combining electrostimulation with feedback from fMRI can provide information about the mechanisms underlying the therapeutic effects, but so far, such studies have been hampered by the lack of technology to conduct safe and accurate experiments. Here we present a system for fMRI compatible electrical stimulation, and the first proof-of-concept neuroimaging data with deep brain stimulation (DBS) in pigs obtained with the device.

NEW METHOD: The system consists of two modules, placed in the control and scanner room, connected by optical fiber. The system also connects to the MRI scanner to timely initiate the stimulation sequence at start of scan. We evaluated the system in four pigs with DBS in the subthalamic nucleus (STN) while we acquired BOLD responses in the STN and neocortex.

RESULTS: We found that the system delivered robust electrical stimuli to the implanted electrode in sync with the preprogrammed fMRI sequence. All pigs displayed a DBS-STN induced neocortical BOLD response, but none in the STN.

COMPARISONS WITH EXISTING METHOD: The system solves three major problems related to electric stimuli and fMRI examinations, namely preventing distortion of the fMRI signal, enabling communication that synchronize the experimental conditions, and surmounting the safety hazards caused by interference with the MRI scanner.

CONCLUSIONS: The fMRI compatible electrical stimulator circumvents previous problems related to electroceuticals and fMRI. The system allows flexible modifications for fMRI designs and stimulation parameters, and can be customized to electroceutical applications beyond DBS.

OriginalsprogEngelsk
Artikelnummer109659
TidsskriftJournal of Neuroscience Methods
Vol/bind378
Sider (fra-til)109659
ISSN0165-0270
DOI
StatusUdgivet - 1 aug. 2022

Bibliografisk note

Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

ID: 79371532