An explorative analysis of ERCC1-19q13 copy number aberrations in a chemonaive stage III colorectal cancer cohort

David Hersi Smith; Ib Jarle Christensen; Niels Frank Jensen; Thomas Bo Markussen; Sven Müller; Hans Jørgen Nielsen; Nils Aage Brünner; Kirsten Vang Nielsen

doi:10.1186/1471-2407-13-489

An explorative analysis of ERCC1-19q13 copy number aberrations in a chemonaive stage III colorectal cancer cohort

David Hersi Smith, Ib Jarle Christensen, Niels Frank Jensen, Thomas Bo Markussen, Sven Müller, Hans Jørgen Nielsen, Nils Aage Brünner, Kirsten Vang Nielsen

5 Citationer (Scopus)

Abstract

Platinum-based chemotherapy has long been used in the treatment of a variety of cancers and functions by inducing DNA damage. ERCC1 and ERCC4 are involved in the removal of this damage and have previously been implicated in resistance to platinum compounds. The aim of the current investigation is to determine the presence, frequency and prognostic impact of ERCC1 or ERCC4 gene copy number alterations in colorectal cancer (CRC).

Originalsprog	Engelsk
Tidsskrift	B M C Cancer
Vol/bind	13
Udgave nummer	1
Sider (fra-til)	489
ISSN	1471-2407
DOI	https://doi.org/10.1186/1471-2407-13-489
Status	Udgivet - 21 okt. 2013

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10.1186/1471-2407-13-489

Citationsformater

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abstract = "Platinum-based chemotherapy has long been used in the treatment of a variety of cancers and functions by inducing DNA damage. ERCC1 and ERCC4 are involved in the removal of this damage and have previously been implicated in resistance to platinum compounds. The aim of the current investigation is to determine the presence, frequency and prognostic impact of ERCC1 or ERCC4 gene copy number alterations in colorectal cancer (CRC).",

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T1 - An explorative analysis of ERCC1-19q13 copy number aberrations in a chemonaive stage III colorectal cancer cohort

AU - Smith, David Hersi

AU - Christensen, Ib Jarle

AU - Jensen, Niels Frank

AU - Markussen, Thomas Bo

AU - Müller, Sven

AU - Nielsen, Hans Jørgen

AU - Brünner, Nils Aage

AU - Nielsen, Kirsten Vang

PY - 2013/10/21

Y1 - 2013/10/21

N2 - Platinum-based chemotherapy has long been used in the treatment of a variety of cancers and functions by inducing DNA damage. ERCC1 and ERCC4 are involved in the removal of this damage and have previously been implicated in resistance to platinum compounds. The aim of the current investigation is to determine the presence, frequency and prognostic impact of ERCC1 or ERCC4 gene copy number alterations in colorectal cancer (CRC).

AB - Platinum-based chemotherapy has long been used in the treatment of a variety of cancers and functions by inducing DNA damage. ERCC1 and ERCC4 are involved in the removal of this damage and have previously been implicated in resistance to platinum compounds. The aim of the current investigation is to determine the presence, frequency and prognostic impact of ERCC1 or ERCC4 gene copy number alterations in colorectal cancer (CRC).

U2 - 10.1186/1471-2407-13-489

DO - 10.1186/1471-2407-13-489

M3 - Journal article

C2 - 24144331

SN - 1471-2407

VL - 13

SP - 489

JO - B M C Cancer

JF - B M C Cancer

IS - 1

ER -

An explorative analysis of ERCC1-19q13 copy number aberrations in a chemonaive stage III colorectal cancer cohort

Abstract

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