TY - JOUR
T1 - An emerging role for p21-activated kinases (Paks) in viral infections
AU - Van den Broeke, Celine
AU - Radu, Maria
AU - Chernoff, Jonathan
AU - Favoreel, Herman W
PY - 2010/3/1
Y1 - 2010/3/1
N2 - p21-activated protein kinases (Paks) are cytosolic serine/threonine protein kinases that act as effectors for small (p21) GTPases of the Cdc42 and Rac families. It has long been established that Paks play a major role in a host of vital cellular functions such as proliferation, survival and motility, and abnormal Pak function is associated with a number of human diseases. Here, we discuss emerging evidence that these enzymes also play a major role in the entry, replication and spread of many important pathogenic human viruses, including HIV. Careful assessment of the potential role of Paks in antiviral immunity will be pivotal to evaluate thoroughly the potential of agents that inhibit Pak as a new class of anti-viral therapeutics.
AB - p21-activated protein kinases (Paks) are cytosolic serine/threonine protein kinases that act as effectors for small (p21) GTPases of the Cdc42 and Rac families. It has long been established that Paks play a major role in a host of vital cellular functions such as proliferation, survival and motility, and abnormal Pak function is associated with a number of human diseases. Here, we discuss emerging evidence that these enzymes also play a major role in the entry, replication and spread of many important pathogenic human viruses, including HIV. Careful assessment of the potential role of Paks in antiviral immunity will be pivotal to evaluate thoroughly the potential of agents that inhibit Pak as a new class of anti-viral therapeutics.
U2 - 10.1016/j.tcb.2009.12.005
DO - 10.1016/j.tcb.2009.12.005
M3 - Journal article
C2 - 20071173
SN - 0962-8924
VL - 20
SP - 160
EP - 169
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 3
ER -