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Region Hovedstaden - en del af Københavns Universitetshospital
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An association study between the norepinephrine transporter gene and depression

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  2. Are TMEM genes potential candidate genes for panic disorder?

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  3. Neuropeptide Y genes and suicidal behaviour among schizophrenic patients

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  4. Sequence analysis of SLITRK1 for var321 in Danish patients with Tourette syndrome and review of the literature

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A potential approach for identification of candidate genes for depression is characterization of chromosomal rearrangements. Through analysis of a chromosome translocation in an individual with recurrent depression, we identified a potential candidate gene: the norepinephrine transporter (NET; SLC6A2 for solute carrier 6 family member 2). The gene is responsible for the reuptake of norepinephrine and dopamine into presynaptic nerve terminals and the norepinephrine system appears to play an important role in depression. We therefore analyzed genetic variants within SLC6A2 for association with depression in 408 affected and 559 control individuals from Denmark. After quality control of the genotypes, 31 of 45 single nucleotide polymorphisms (SNPs) were left for analyses. One SNP showed a nominal association with depression but did not survive correction for multiple testing. The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population.
OriginalsprogEngelsk
TidsskriftPsychiatric Genetics
Vol/bind23
Udgave nummer5
Sider (fra-til)217-221
Antal sider5
ISSN0955-8829
DOI
StatusUdgivet - okt. 2013

ID: 39653571