An allosteric enhancer of M(4) muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine

Ditte Dencker Nielsen; Pia Weikop; Gunnar Sørensen; David P D Woldbye; Gitta Wörtwein; Jürgen Wess; Anders Fink-Jensen

doi:10.1007/s00213-012-2751-8

An allosteric enhancer of M(4) muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine

Ditte Dencker Nielsen, Pia Weikop, Gunnar Sørensen, David P D Woldbye, Gitta Wörtwein, Jürgen Wess, Anders Fink-Jensen

Psykiatrisk Center København BFH

47 Citationer (Scopus)

Abstract

The mesostriatal dopamine system plays a key role in mediating the reinforcing effects of psychostimulant drugs like cocaine. The muscarinic M(4) acetylcholine receptor subtype is centrally involved in the regulation of dopamine release in striatal areas. Consequently, striatal M(4) receptors could be a novel target for modulating psychostimulant effects of cocaine.

Originalsprog	Engelsk
Tidsskrift	Psychopharmacology
Vol/bind	224
Udgave nummer	2
Sider (fra-til)	277-87
Antal sider	11
ISSN	0033-3158
DOI	https://doi.org/10.1007/s00213-012-2751-8
Status	Udgivet - 2012

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AU - Wörtwein, Gitta

AU - Wess, Jürgen

AU - Fink-Jensen, Anders

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AB - The mesostriatal dopamine system plays a key role in mediating the reinforcing effects of psychostimulant drugs like cocaine. The muscarinic M(4) acetylcholine receptor subtype is centrally involved in the regulation of dopamine release in striatal areas. Consequently, striatal M(4) receptors could be a novel target for modulating psychostimulant effects of cocaine.

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An allosteric enhancer of M(4) muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine

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