Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

An 18-Year Nationwide Cohort Study on The Association Between Diverticulitis and Colon Cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Comment on "Epidural Analgesia (TEA) vs. IV-PCA After Open Liver Surgery"

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  2. Robotic Surgery Is Less Physically Demanding Than Laparoscopic Surgery: Paired Cross Sectional Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Response to Comment on "Polypropylene Mesh and Fertility"

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  4. The S100A10 Pathway Mediates an Occult Hyperfibrinolytic Subtype in Trauma Patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Closure of the fascial defect during laparoscopic umbilical hernia repair: a randomized clinical trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Incidence of Inguinal Hernia after Radical Prostatectomy: A Systematic Review and Meta-Analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Kønsmodificerende kirurgi i Danmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Outcome Measures in Gender-Confirming Chest Surgery: A Systematic Scoping Review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

OBJECTIVE: To investigate the association between diverticulitis and colon cancer in a large, nationwide cohort study.

BACKGROUND: Diverticulitis is a common disease, especially in the Western world. Previous articles have investigated the association between diverticulitis and colon cancer with inconclusive results.

METHODS: We conducted a population-based cohort study based on longitudinal Danish national registers with data from the period 1995 to 2012. Data were extracted from comprehensive Danish national registers containing information from both public and private hospitals. Patients with diverticulitis were identified from the registers and matched by sex and age (± 1 year) with a ratio of 1:10 to people who did not have a registration of diverticulitis or diverticulosis. Main outcome was the event of colon cancer. Subgroup analyses were performed to investigate the effect of colonoscopies and treatment on the colon cancer rate after diverticulitis.

RESULTS: A total of 445,456 people were included, of whom 40,496 had a diagnosis of diverticulitis. The incidence of colon cancer in the group with diverticulitis (4.3%) and the group without diverticulitis (2.3%) differed significantly (P < 0.001) with an incidence rate ratio of 1.86 (95% confidence interval, CI, 1.77-1.96). When adjusted for possible confounders, the association between diverticulitis and cancer remained significant with an odds ratio (OR) of 2.20 (95% CI 2.08-2.32) (P < 0.001). Those with diverticulitis, who had no colonoscopy, had an increased risk of colon cancer compared with those without both diverticulitis and colonoscopy with an OR of 2.72 (95% CI 2.64-2.94) (P < 0.001).

CONCLUSIONS: We found a strong association between development of diverticulitis and colon cancer. This raises several questions regarding the possible causal association and warrants further studies. Patients with diverticulitis should undergo endoscopic surveillance for colon cancer.

OriginalsprogEngelsk
TidsskriftAnnals of Surgery
Vol/bind265
Udgave nummer5
Sider (fra-til)954-59
ISSN0003-4932
DOI
StatusUdgivet - 2017

ID: 49675986