Amyloid-related biomarkers and axonal damage proteins in parkinsonian syndromes

Sara Bech, Lena E Hjermind, Lisette Salvesen, Jørgen E Nielsen, Niels Henrik Helweg Heegaard, Henrik L Jørgensen, Lars Rosengren, Kaj Blennow, Henrik Zetterberg, Kristian Winge

40 Citationer (Scopus)

Abstract

Clinical differentiation between parkinsonian syndromes (PS) remains a challenge despite well-established clinical diagnostic criteria. Specific diagnostic biomarkers have yet to be identified, though in recent years, studies have been published on the aid of certain brain related proteins (BRP) in the diagnosing of PS. We investigated the levels of the light subunit of neurofilament triplet protein (NF-L), total tau and phosphorylated tau, amyloid-β(1-42), and the soluble α- and β-cleaved fragments of amyloid precursor proteins in a cohort of patients with various PS.
OriginalsprogEngelsk
TidsskriftParkinsonism & related disorders
Vol/bind18
Udgave nummer1
Sider (fra-til)69-72
Antal sider4
ISSN1353-8020
DOI
StatusUdgivet - 2012

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