Amplification of epidermal growth factor receptor gene in renal cell carcinoma

Iman El-Hariry; Thomas Powles; Mike R Lau; Cora N Sternberg; Alain Ravaud; Hans von der Maase; Niko Zantl; Peter Mathias Harper; Frédéric Rolland; Bruno Audhuy; Friederike Barthel; Jean-Pascal Machiels; Pina Patel; Ernst-Dietrick Kreuser; Robert E Hawkins

doi:10.1016/j.ejca.2010.01.011

Amplification of epidermal growth factor receptor gene in renal cell carcinoma

Iman El-Hariry, Thomas Powles, Mike R Lau, Cora N Sternberg, Alain Ravaud, Hans von der Maase, Niko Zantl, Peter Mathias Harper, Frédéric Rolland, Bruno Audhuy, Friederike Barthel, Jean-Pascal Machiels, Pina Patel, Ernst-Dietrick Kreuser, Robert E Hawkins

12 Citationer (Scopus)

Abstract

Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC.

Originalsprog	Engelsk
Tidsskrift	European journal of cancer (Oxford, England : 1990)
Vol/bind	46
Udgave nummer	5
Sider (fra-til)	859-62
Antal sider	4
DOI	https://doi.org/10.1016/j.ejca.2010.01.011
Status	Udgivet - 1 mar. 2010

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10.1016/j.ejca.2010.01.011

Citationsformater

El-Hariry, I., Powles, T., Lau, M. R., Sternberg, C. N., Ravaud, A., von der Maase, H., Zantl, N., Harper, P. M., Rolland, F., Audhuy, B., Barthel, F., Machiels, J.-P., Patel, P., Kreuser, E.-D., & Hawkins, R. E. (2010). Amplification of epidermal growth factor receptor gene in renal cell carcinoma. European journal of cancer (Oxford, England : 1990), 46(5), 859-62. https://doi.org/10.1016/j.ejca.2010.01.011

El-Hariry, I, Powles, T, Lau, MR, Sternberg, CN, Ravaud, A, von der Maase, H, Zantl, N, Harper, PM, Rolland, F, Audhuy, B, Barthel, F, Machiels, J-P, Patel, P, Kreuser, E-D & Hawkins, RE 2010, 'Amplification of epidermal growth factor receptor gene in renal cell carcinoma', European journal of cancer (Oxford, England : 1990), bind 46, nr. 5, s. 859-62. https://doi.org/10.1016/j.ejca.2010.01.011

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abstract = "Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC.",

author = "Iman El-Hariry and Thomas Powles and Lau, {Mike R} and Sternberg, {Cora N} and Alain Ravaud and {von der Maase}, Hans and Niko Zantl and Harper, {Peter Mathias} and Fr{\'e}d{\'e}ric Rolland and Bruno Audhuy and Friederike Barthel and Jean-Pascal Machiels and Pina Patel and Ernst-Dietrick Kreuser and Hawkins, {Robert E}",

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doi = "10.1016/j.ejca.2010.01.011",

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T1 - Amplification of epidermal growth factor receptor gene in renal cell carcinoma

AU - El-Hariry, Iman

AU - Powles, Thomas

AU - Lau, Mike R

AU - Sternberg, Cora N

AU - Ravaud, Alain

AU - von der Maase, Hans

AU - Zantl, Niko

AU - Harper, Peter Mathias

AU - Rolland, Frédéric

AU - Audhuy, Bruno

AU - Barthel, Friederike

AU - Machiels, Jean-Pascal

AU - Patel, Pina

AU - Kreuser, Ernst-Dietrick

AU - Hawkins, Robert E

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC.

AB - Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC.

U2 - 10.1016/j.ejca.2010.01.011

DO - 10.1016/j.ejca.2010.01.011

M3 - Journal article

C2 - 20167476

SN - 1879-0852

VL - 46

SP - 859

EP - 862

JO - European journal of cancer (Oxford, England : 1990)

JF - European journal of cancer (Oxford, England : 1990)

IS - 5

ER -

Amplification of epidermal growth factor receptor gene in renal cell carcinoma

Abstract

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