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Aluminium contact allergy without vaccination granulomas: A systematic review and meta-analysis

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@article{5c3cae76c29d4b8eb87127936fff1a64,
title = "Aluminium contact allergy without vaccination granulomas: A systematic review and meta-analysis",
abstract = "Aluminium contact allergy is mainly seen as granulomas following immunization with aluminium-adsorbed vaccines and contact allergy following epicutaneous exposure may be overlooked. To investigate the prevalence of aluminium allergy confirmed by patch testing, with no association with vaccination granulomas, and explore whether epicutaneous exposure to aluminium can contribute to allergic contact dermatitis. Two authors independently searched PubMed and MEDLINE (OVID) for case studies on contact allergy to aluminium proven by patch testing. Age-stratified meta-analyses to calculate the pooled prevalence were performed. Twenty-five studies describing a total of 73 cases were included in the review. Seven studies were suitable for meta-analyses. The prevalence of aluminium contact allergy was 5.61% (95% confidence interval [CI] 0.12%-11.08%) for children and 0.36% (95% CI 0.04%-0.67%) for adults. The studies described a variety of epicutaneous exposures, where metallic aluminium, topical medicaments, and deodorants were the main sources. Aluminium sensitization without a known exposure source was described in 10 of the 25 articles. The prevalence of aluminium contact allergy in the general public may be higher than expected and not solely related to vaccination granulomas. However, the clinical relevance is rare if not related to granulomas.",
keywords = "aluminium, contact allergy, dermatitis, epicutaneous exposure, granuloma, meta-analysis, patch test, prevalence, sensitization, vaccine",
author = "Hoffmann, {Stine Skovbo} and Michael Wennervaldt and Farzad Alinaghi and Simonsen, {Anne Birgitte} and Johansen, {Jeanne Duus}",
note = "{\textcopyright} 2021 John Wiley & Sons A/S . Published by John Wiley & Sons Ltd.",
year = "2021",
month = aug,
doi = "10.1111/cod.13852",
language = "English",
volume = "85",
pages = "129--135",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Wiley-Blackwell Munksgaard",
number = "2",

}

RIS

TY - JOUR

T1 - Aluminium contact allergy without vaccination granulomas

T2 - A systematic review and meta-analysis

AU - Hoffmann, Stine Skovbo

AU - Wennervaldt, Michael

AU - Alinaghi, Farzad

AU - Simonsen, Anne Birgitte

AU - Johansen, Jeanne Duus

N1 - © 2021 John Wiley & Sons A/S . Published by John Wiley & Sons Ltd.

PY - 2021/8

Y1 - 2021/8

N2 - Aluminium contact allergy is mainly seen as granulomas following immunization with aluminium-adsorbed vaccines and contact allergy following epicutaneous exposure may be overlooked. To investigate the prevalence of aluminium allergy confirmed by patch testing, with no association with vaccination granulomas, and explore whether epicutaneous exposure to aluminium can contribute to allergic contact dermatitis. Two authors independently searched PubMed and MEDLINE (OVID) for case studies on contact allergy to aluminium proven by patch testing. Age-stratified meta-analyses to calculate the pooled prevalence were performed. Twenty-five studies describing a total of 73 cases were included in the review. Seven studies were suitable for meta-analyses. The prevalence of aluminium contact allergy was 5.61% (95% confidence interval [CI] 0.12%-11.08%) for children and 0.36% (95% CI 0.04%-0.67%) for adults. The studies described a variety of epicutaneous exposures, where metallic aluminium, topical medicaments, and deodorants were the main sources. Aluminium sensitization without a known exposure source was described in 10 of the 25 articles. The prevalence of aluminium contact allergy in the general public may be higher than expected and not solely related to vaccination granulomas. However, the clinical relevance is rare if not related to granulomas.

AB - Aluminium contact allergy is mainly seen as granulomas following immunization with aluminium-adsorbed vaccines and contact allergy following epicutaneous exposure may be overlooked. To investigate the prevalence of aluminium allergy confirmed by patch testing, with no association with vaccination granulomas, and explore whether epicutaneous exposure to aluminium can contribute to allergic contact dermatitis. Two authors independently searched PubMed and MEDLINE (OVID) for case studies on contact allergy to aluminium proven by patch testing. Age-stratified meta-analyses to calculate the pooled prevalence were performed. Twenty-five studies describing a total of 73 cases were included in the review. Seven studies were suitable for meta-analyses. The prevalence of aluminium contact allergy was 5.61% (95% confidence interval [CI] 0.12%-11.08%) for children and 0.36% (95% CI 0.04%-0.67%) for adults. The studies described a variety of epicutaneous exposures, where metallic aluminium, topical medicaments, and deodorants were the main sources. Aluminium sensitization without a known exposure source was described in 10 of the 25 articles. The prevalence of aluminium contact allergy in the general public may be higher than expected and not solely related to vaccination granulomas. However, the clinical relevance is rare if not related to granulomas.

KW - aluminium

KW - contact allergy

KW - dermatitis

KW - epicutaneous exposure

KW - granuloma

KW - meta-analysis

KW - patch test

KW - prevalence

KW - sensitization

KW - vaccine

UR - http://www.scopus.com/inward/record.url?scp=85104326387&partnerID=8YFLogxK

U2 - 10.1111/cod.13852

DO - 10.1111/cod.13852

M3 - Review

C2 - 33797096

VL - 85

SP - 129

EP - 135

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 2

ER -

ID: 67624715