Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Alternatives to Outdoor Daylight Illumination for Photodynamic Therapy--Use of Greenhouses and Artificial Light Sources

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Gel-Based Proteomics of Clinical Samples Identifies Potential Serological Biomarkers for Early Detection of Colorectal Cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Methods and guidelines for measurement of glucagon in plasma

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Xeno-Free Propagation of Spermatogonial Stem Cells from Infant Boys

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Matrix Metalloproteinase-3 is Key Effector of TNF-α-Induced Collagen Degradation in Skin

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Daylight PDT acts by continuous activation of PpIX

    Publikation: Bidrag til tidsskriftLederForskningpeer review

Vis graf over relationer

Daylight-mediated photodynamic therapy (daylight PDT) is a simple and pain free treatment of actinic keratoses. Weather conditions may not always allow daylight PDT outdoors. We compared the spectrum of five different lamp candidates for indoor "daylight PDT" and investigated their ability to photobleach protoporphyrin IX (PpIX). Furthermore, we measured the amount of PpIX activating daylight available in a glass greenhouse, which can be an alternative when it is uncomfortable for patients to be outdoors. The lamps investigated were: halogen lamps (overhead and slide projector), white light-emitting diode (LED) lamp, red LED panel and lamps used for conventional PDT. Four of the five light sources were able to photobleach PpIX completely. For halogen light and the red LED lamp, 5000 lux could photobleach PpIX whereas 12,000 lux were needed for the white LED lamp. Furthermore, the greenhouse was suitable for daylight PDT since the effect of solar light is lowered only by 25%. In conclusion, we found four of the five light sources and the greenhouse usable for indoor daylight PDT. The greenhouse is beneficial when the weather outside is rainy or windy. Only insignificant ultraviolet B radiation (UVB) radiation passes through the greenhouse glass, so sun protection is not needed.

OriginalsprogEngelsk
TidsskriftInternational Journal of Molecular Sciences
Vol/bind17
Udgave nummer3
Sider (fra-til)309
ISSN1661-6596
DOI
StatusUdgivet - 29 feb. 2016

ID: 49585011