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Region Hovedstaden - en del af Københavns Universitetshospital
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Alternating treatment with didanosine and zidovudine versus either drug alone for the treatment of advanced HIV infection. The Alter Study. Nordic HIV Therapy Group

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  • J Gerstoft
  • H Melander
  • J N Bruun
  • C Pedersen
  • Peter C. Gøtzsche
  • O Berglund
  • L Mathiesen
  • P Skinhłj
  • S R Norrby
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The efficacy and safety of an alternating regime with zidovudine and didanosine versus treatment with either drug alone were investigated in a randomized, open, controlled trial, 552 patients with advanced HIV infection, 47% of whom had received prior treatment with zidovudine, were enrolled. The patients were randomly assigned to zidovudine 600 mg/day, didanosine 400 mg/day or 4-week alternations with the 2 drugs in the same dose. The study had a median length of follow-up of 88 weeks. In the overall analyses, time to death (p = 0.48) and time to death or new AIDA event (0.80) were equally distributed between the 3 treatment groups. In the subgroup of patients with a CD4 count <100 x 10(6)/l the survival was longer in the alternating arm (p <0.005) primarily because of differences among zidovudine naive patients. The alternating regime was better tolerated than the 2 monotherapies, with a longer time to dose reduction or withdrawal owing to side effects (p <0.001).
OriginalsprogEngelsk
TidsskriftScandinavian Journal of Infectious Diseases
Vol/bind29
Udgave nummer2
Sider (fra-til)121-8
Antal sider8
ISSN0036-5548
StatusUdgivet - 1997

ID: 38982743