Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Altered orbitofrontal sulcogyral patterns in gambling disorder: a multicenter study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Reporting guidelines on remotely collected electronic mood data in mood disorder (eMOOD)-recommendations

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Stratification and prediction of remission in first-episode psychosis patients: the OPTiMiSE cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Accessibility of cortical regions to focal TES: Dependence on spatial position, safety, and practical constraints

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Yansong Li
  • Zixiang Wang
  • Isabelle Boileau
  • Jean-Claude Dreher
  • Sofie Gelskov
  • Alexander Genauck
  • Juho Joutsa
  • Valtteri Kaasinen
  • José C Perales
  • Nina Romanczuk-Seiferth
  • Cristian M Ruiz de Lara
  • Hartwig R Siebner
  • Ruth J van Holst
  • Tim van Timmeren
  • Guillaume Sescousse
Vis graf over relationer

Gambling disorder is a serious psychiatric condition characterized by decision-making and reward processing impairments that are associated with dysfunctional brain activity in the orbitofrontal cortex (OFC). However, it remains unclear whether OFC functional abnormalities in gambling disorder are accompanied by structural abnormalities. We addressed this question by examining the organization of sulci and gyri in the OFC. This organization is in place very early and stable across life, such that OFC sulcogyral patterns (classified into Types I, II, and III) can be regarded as potential pre-morbid markers of pathological conditions. We gathered structural brain data from nine existing studies, reaching a total of 165 individuals with gambling disorder and 159 healthy controls. Our results, supported by both frequentist and Bayesian statistics, show that the distribution of OFC sulcogyral patterns is skewed in individuals with gambling disorder, with an increased prevalence of Type II pattern compared with healthy controls. Examination of gambling severity did not reveal any significant relationship between OFC sulcogyral patterns and disease severity. Altogether, our results provide evidence for a skewed distribution of OFC sulcogyral patterns in gambling disorder and suggest that pattern Type II might represent a pre-morbid structural brain marker of the disease. It will be important to investigate more closely the functional implications of these structural abnormalities in future work.

OriginalsprogEngelsk
TidsskriftTranslational psychiatry
Vol/bind9
Udgave nummer1
Sider (fra-til)186
ISSN2158-3188
DOI
StatusUdgivet - 5 aug. 2019

ID: 57721712