Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Altered auditory processing and effective connectivity in 22q11.2 deletion syndrome

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Schizophrenia polygenic risk scores, urbanicity and treatment-resistant schizophrenia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Emotion recognition latency, but not accuracy, relates to real life functioning in individuals at ultra-high risk for psychosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. First-rank symptoms and self-disorders in schizophrenia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Cerebellar - premotor cortex interactions underlying visuomotor adaptation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Accurate and robust whole-head segmentation from magnetic resonance images for individualized head modeling

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Maintenance of muscle strength following a one-year resistance training program in older adults

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

22q11.2 deletion syndrome (22q11.2DS) is one of the most common copy number variants and confers a markedly increased risk for schizophrenia. As such, 22q11.2DS is a homogeneous genetic liability model which enables studies to delineate functional abnormalities that may precede disease onset. Mismatch negativity (MMN), a brain marker of change detection, is reduced in people with schizophrenia compared to healthy controls. Using dynamic causal modelling (DCM), previous studies showed that top-down effective connectivity linking the frontal and temporal cortex is reduced in schizophrenia relative to healthy controls in MMN tasks. In the search for early risk-markers for schizophrenia we investigated the neural basis of change detection in a group with 22q11.2DS. We recorded high-density EEG from 19 young non-psychotic 22q11.2 deletion carriers, as well as from 27 healthy non-carriers with comparable age distribution and sex ratio, while they listened to a sequence of sounds arranged in a roving oddball paradigm. Despite finding no significant reduction in the MMN responses, whole-scalp spatiotemporal analysis of responses to the tones revealed a greater fronto-temporal N1 component in the 22q11.2 deletion carriers. DCM showed reduced intrinsic connection within right primary auditory cortex as well as in the top-down, connection from the right inferior frontal gyrus to right superior temporal gyrus for 22q11.2 deletion carriers although not surviving correction for multiple comparison. We discuss these findings in terms of reduced adaptation and a general increased sensitivity to tones in 22q11.2DS.

OriginalsprogEngelsk
TidsskriftSchizophrenia Research
ISSN0920-9964
DOI
StatusUdgivet - 30 jan. 2018

ID: 52666277