Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Alterations of the visual pathways in congenital blindness.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Sensory defunctionalization induced by 8% topical capsaicin treatment in a model of ultraviolet-B-induced cutaneous hyperalgesia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Influence of visual feedback, hand dominance and sex on individuated finger movements

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Improved assessment of outcomes following transient global cerebral ischemia in mice

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Effects of dopaminergic treatment on functional cortico-cortical connectivity in Parkinson's disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Cue integration and the perception of action in intentional binding

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Elevated body weight modulates subcortical volume change and associated clinical response following electroconvulsive therapy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Intradural artery dilation during experimentally induced migraine attacks

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
We used whole brain MRI voxel-based morphometry (VBM) to study the anatomical organization of the visual system in congenitally blind (CB) adults. Eleven CB without a history of visual perception were compared with 21 age- and sex-matched normal-sighted controls (NS). CB showed significant atrophy of the geniculo-striate system, encompassing the optic nerves, the optic chiasm, the optic radiations and the primary visual cortex (BA17). The volume decrease in BA17 reached 25% in both hemispheres. The pulvinar and its projections to the associative visual areas were also dramatically altered, BA18/19 and the middle temporal cortex (MT) showing volume reductions of up to 20%. Additional significant white matter alterations were observed in the inferior longitudinal tract and in the posterior part of the corpus callosum, which links the visual areas of both hemispheres. Our data indicate that the afferent projections to the visual cortex in CB are largely atrophied. Despite the massive volume reductions in the occipital lobes, there is compelling evidence from the literature (reviewed in Noppeney 2007; Ptito and Kupers 2005) that blind subjects activate their visual cortex when performing tasks that involve somatosensory or auditory inputs, suggesting a reorganization of the neural pathways that transmit sensory information to the visual cortex.
Udgivelsesdato: 2008-Jan-26
OriginalsprogEngelsk
TidsskriftExperimental Brain Research
Vol/bind187
Udgave nummer1
Sider (fra-til)41-9
ISSN0014-4819
DOI
StatusUdgivet - 2008

ID: 32541026