Alteration in Pancreatic Islet Function in Human Immunodeficiency Virus

Abstract

Molecular mechanisms behind the defects in insulin production and secretion associated with antihuman immunodeficiency virus (anti-HIV) therapy and the development of HIV-associated lipodystrophy syndrome (HALS) are discussed in this article. Data suggesting insulin resistance on the beta cell and defects in first-phase insulin release of HALS patients are presented. Hepatic extraction of insulin, nonglucose insulin secretagogues and insulin-like growth factor release may exert influence on the demand of circulating insulin and on insulin secretion in HIV-infected patients. Finally, the paucity in understanding the incretin effects in HIV and HIV therapy in relation to insulin secretion is highlighted.

OriginalsprogEngelsk
TidsskriftEndocrinology and Metabolism Clinics of North America
Vol/bind43
Udgave nummer3
Sider (fra-til)697-708
Antal sider12
ISSN0889-8529
DOI
StatusUdgivet - 3 sep. 2014

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