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Region Hovedstaden - en del af Københavns Universitetshospital
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Alteplase (rtPA) treatment of intraventricular hematoma (IVH): safety of an efficient methodological approach for rapid clot removal

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  1. Living with the cerebellar mutism syndrome: long-term challenges of the diagnosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Hypozincaemia is associated with severity of aneurysmal subarachnoid haemorrhage: a retrospective cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Tumor miRNA expression profile is related to vestibular schwannoma growth rate

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Subdural contrast effusion during endovascular therapy: case report

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  5. Response to: neurosurgical procedures performed during residency in Europe-preliminary numbers and time trends

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  1. Laser Ablation of Abnormal Neurological Tissue Using Robotic Neuroblate System (LAANTERN): Procedural Safety and Hospitalization

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Clinical and histopathological predictors of outcome in malignant meningioma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Organisering af Perifer Nervekirurgi i Danmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Adaptive hybrid surgery analysis (AHSA) for adjuvant gamma knife radiosurgery treatment of vestibular schwannoma residuals

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Delayed cerebral ischaemia in patients with aneurysmal subarachnoid haemorrhage: Functional outcome and long-term mortality

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Intraventricular hemorrhage (IVH) subsequent to intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH) is associated with high mortality and morbidity. The use of fibrinolytic agents to treat this condition has previously been reported in small clinical trials with limited numbers of patients. Variability regarding inclusion criteria, method of administration and outcome have made it difficult to draw firm conclusions regarding the efficacy of antifibrinolytic therapy. Nine patients with CT-diagnosed IVH were treated with Alteplase intrathecally for 3 to 5 days according to the CT-verified clearance of IVH. After the treatment period, a repeat CT scan was performed to evaluate treatment effect.In this safety study, we achieved rapid removal of IVH compared to retrospective controls, without incidents of re-bleeding, with only 33% permanent shunt placements and a neurological outcome of GOS of 4-5 in 44% of the patients. Based on the above results, the treatment protocol was considered safe and highly effective. A prospective randomized national multicenter trial has been initiated in order to evaluate the efficacy of this novel method also in terms of outcome and shunt dependency.
OriginalsprogEngelsk
TidsskriftActa Neurochirurgica
Vol/bind111
Sider (fra-til)409-13
Antal sider5
ISSN0001-6268
DOI
StatusUdgivet - 2011

ID: 33273901