Allogeneic hematopoietic stem-cell transplantation for acute myeloid leukemia in remission: comparison of intravenous busulfan plus cyclophosphamide (Cy) versus total-body irradiation plus Cy as conditioning regimen--a report from the acute leukemia working party of the European group for blood and marrow transplantation

Arnon Nagler, Vanderson Rocha, Myriam Labopin, Ali Unal, Tarek Ben Othman, Antonio Campos, Liisa Volin, Xavier Poire, Mahmoud Aljurf, Tamás Masszi, Gerard Socie, Henrik Sengelov, Mauricette Michallet, Jakob Passweg, Hendrik Veelken, Ibrahim Yakoub-Agha, Avichai Shimoni, Mohamad Mohty

    133 Citationer (Scopus)

    Abstract

    Cyclophosphamide (Cy) combined with total-body irradiation (TBI) or with busulfan (Bu) are currently the most common myeloablative regimens used in allogeneic stem-cell transplantation (alloSCT) in adults with acute myelogenous leukemia (AML). Intravenous (IV) Bu has more predictable bioavailability and a safer toxicity profile than the oral formulation. Comparative studies of outcomes have been performed between oral Bu/Cy and Cy/TBI, but there have been no comparative trials in the era of IV Bu.
    OriginalsprogEngelsk
    TidsskriftJournal of clinical oncology : official journal of the American Society of Clinical Oncology
    Vol/bind31
    Udgave nummer28
    Sider (fra-til)3549-56
    Antal sider8
    ISSN0732-183X
    DOI
    StatusUdgivet - 1 okt. 2013

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