Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets

José L Santos; Rolando De la Cruz; Claus Holst; Katrine Grau; Carolina Naranjo; Alberto Maiz; Arne Astrup; Wim H M Saris; Ian MacDonald; Jean-Michel Oppert; Torben Hansen; Oluf Pedersen; Thorkild I A Sorensen; J Alfredo Martinez; NUGENOB Consortium

doi:10.1371/journal.pone.0019934

Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets

José L Santos
, Rolando De la Cruz
, Claus Holst
, Katrine Grau
, Carolina Naranjo
, Alberto Maiz
, Arne Astrup
, Wim H M Saris
, Ian MacDonald
, Jean-Michel Oppert
, Torben Hansen
, Oluf Pedersen
, Thorkild I A Sorensen
, J Alfredo Martinez
, NUGENOB Consortium

24 Citationer (Scopus)

Abstract

The melanocortin system plays an important role in energy homeostasis. Mice genetically deficient in the melanocortin-3 receptor gene have a normal body weight with increased body fat, mild hypophagia compared to wild-type mice. In humans, Thr6Lys and Val81Ile variants of the melanocortin-3 receptor gene (MC3R) have been associated with childhood obesity, higher BMI Z-score and elevated body fat percentage compared to non-carriers. The aim of this study is to assess the association in adults between allelic variants of MC3R with weight loss induced by energy-restricted diets.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	6
Udgave nummer	6
Sider (fra-til)	e19934
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0019934
Status	Udgivet - 2011

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10.1371/journal.pone.0019934

Citationsformater

Santos, J. L., De la Cruz, R., Holst, C., Grau, K., Naranjo, C., Maiz, A., Astrup, A., Saris, W. H. M., MacDonald, I., Oppert, J.-M., Hansen, T., Pedersen, O., Sorensen, T. I. A., Martinez, J. A., & NUGENOB Consortium (2011). Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets. P L o S One, 6(6), e19934. https://doi.org/10.1371/journal.pone.0019934

Santos, JL, De la Cruz, R, Holst, C, Grau, K, Naranjo, C, Maiz, A, Astrup, A, Saris, WHM, MacDonald, I, Oppert, J-M, Hansen, T, Pedersen, O, Sorensen, TIA, Martinez, JA & NUGENOB Consortium 2011, 'Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets', P L o S One, bind 6, nr. 6, s. e19934. https://doi.org/10.1371/journal.pone.0019934

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title = "Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets",

abstract = "The melanocortin system plays an important role in energy homeostasis. Mice genetically deficient in the melanocortin-3 receptor gene have a normal body weight with increased body fat, mild hypophagia compared to wild-type mice. In humans, Thr6Lys and Val81Ile variants of the melanocortin-3 receptor gene (MC3R) have been associated with childhood obesity, higher BMI Z-score and elevated body fat percentage compared to non-carriers. The aim of this study is to assess the association in adults between allelic variants of MC3R with weight loss induced by energy-restricted diets.",

keywords = "Adipose Tissue, Adult, Alleles, Animals, Diet, Fat-Restricted, Diet, Reducing, Dietary Fats, Energy Metabolism, Female, Genotype, Humans, Linkage Disequilibrium, Male, Mice, Middle Aged, Obesity, Polymorphism, Single Nucleotide, Receptor, Melanocortin, Type 3, Waist Circumference, Weight Loss, Young Adult",

author = "Santos, \{Jos{\'e} L\} and \{De la Cruz\}, Rolando and Claus Holst and Katrine Grau and Carolina Naranjo and Alberto Maiz and Arne Astrup and Saris, \{Wim H M\} and Ian MacDonald and Jean-Michel Oppert and Torben Hansen and Oluf Pedersen and Sorensen, \{Thorkild I A\} and Martinez, \{J Alfredo\} and \{NUGENOB Consortium\}",

year = "2011",

doi = "10.1371/journal.pone.0019934",

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AU - Santos, José L

AU - De la Cruz, Rolando

AU - Holst, Claus

AU - Grau, Katrine

AU - Naranjo, Carolina

AU - Maiz, Alberto

AU - Astrup, Arne

AU - Saris, Wim H M

AU - MacDonald, Ian

AU - Oppert, Jean-Michel

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Sorensen, Thorkild I A

AU - Martinez, J Alfredo

AU - NUGENOB Consortium

PY - 2011

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N2 - The melanocortin system plays an important role in energy homeostasis. Mice genetically deficient in the melanocortin-3 receptor gene have a normal body weight with increased body fat, mild hypophagia compared to wild-type mice. In humans, Thr6Lys and Val81Ile variants of the melanocortin-3 receptor gene (MC3R) have been associated with childhood obesity, higher BMI Z-score and elevated body fat percentage compared to non-carriers. The aim of this study is to assess the association in adults between allelic variants of MC3R with weight loss induced by energy-restricted diets.

AB - The melanocortin system plays an important role in energy homeostasis. Mice genetically deficient in the melanocortin-3 receptor gene have a normal body weight with increased body fat, mild hypophagia compared to wild-type mice. In humans, Thr6Lys and Val81Ile variants of the melanocortin-3 receptor gene (MC3R) have been associated with childhood obesity, higher BMI Z-score and elevated body fat percentage compared to non-carriers. The aim of this study is to assess the association in adults between allelic variants of MC3R with weight loss induced by energy-restricted diets.

KW - Adipose Tissue

KW - Adult

KW - Alleles

KW - Animals

KW - Diet, Fat-Restricted

KW - Diet, Reducing

KW - Dietary Fats

KW - Energy Metabolism

KW - Female

KW - Genotype

KW - Humans

KW - Linkage Disequilibrium

KW - Male

KW - Mice

KW - Middle Aged

KW - Obesity

KW - Polymorphism, Single Nucleotide

KW - Receptor, Melanocortin, Type 3

KW - Waist Circumference

KW - Weight Loss

KW - Young Adult

U2 - 10.1371/journal.pone.0019934

DO - 10.1371/journal.pone.0019934

M3 - Journal article

C2 - 21695122

SN - 1932-6203

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SP - e19934

JO - P L o S One

JF - P L o S One

IS - 6

ER -

Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets

Abstract

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