TY - JOUR
T1 - Allelic loss of chromosome 2p21-16.3 is associated with reduced survival in sporadic colorectal cancer
AU - Bisgaard, M L
AU - Jäger, A C
AU - Dalgaard, P
AU - Søndergaard, J O
AU - Rehfeld, J F
AU - Nielsen, F C
PY - 2001/4
Y1 - 2001/4
N2 - BACKGROUND: Since allelic loss of genes involved in the development of colorectal cancer could serve as prognostic markers, we examined the correlation between loss of markers linked to the hMSH2/hMSH6 (2p21-16.3), hMLH1 (3p21.3), APC (5q21-22), p53 (17p13.1) and DCC (18q21.3) loci and survival in a series of 64 consecutively collected colorectal cancers.METHODS: The association between allelic loss and survival was analysed by univariate and multivariate tests to identify independent variables of survival.RESULTS: Loss of chromosome 2p21-16.3 reduced the overall 5-year survival from 52% to 15% (P = 0.0003). The prognostic significance was evident in patients with Dukes' A + B as well as Dukes' C tumours. A multivariate analysis comparing Dukes' staging, age at diagnosis, tumour localization, sex, loss of chromosome 2p21-16.3, 3p21.3, 5q21-22, 17p13.1 or 18q21.3 and microsatellite instability showed that only Dukes' staging (hazard ratio 3.0; 1.4-6.5 with 95% confidence interval, P = 0.0065) and loss of 2p21-16.3 (hazard ratio 6.2; 2.3-16.8 with 95% confidence interval, P = 0.0006) were independent variables of survival. Loss of 2p21-16.3 was, moreover, associated with increased loss of the other tumour suppressor loci (P = 0.012).CONCLUSIONS: The results show that loss of 2p21-16.3 is an independent indicator of survival in patients with colorectal cancer.
AB - BACKGROUND: Since allelic loss of genes involved in the development of colorectal cancer could serve as prognostic markers, we examined the correlation between loss of markers linked to the hMSH2/hMSH6 (2p21-16.3), hMLH1 (3p21.3), APC (5q21-22), p53 (17p13.1) and DCC (18q21.3) loci and survival in a series of 64 consecutively collected colorectal cancers.METHODS: The association between allelic loss and survival was analysed by univariate and multivariate tests to identify independent variables of survival.RESULTS: Loss of chromosome 2p21-16.3 reduced the overall 5-year survival from 52% to 15% (P = 0.0003). The prognostic significance was evident in patients with Dukes' A + B as well as Dukes' C tumours. A multivariate analysis comparing Dukes' staging, age at diagnosis, tumour localization, sex, loss of chromosome 2p21-16.3, 3p21.3, 5q21-22, 17p13.1 or 18q21.3 and microsatellite instability showed that only Dukes' staging (hazard ratio 3.0; 1.4-6.5 with 95% confidence interval, P = 0.0065) and loss of 2p21-16.3 (hazard ratio 6.2; 2.3-16.8 with 95% confidence interval, P = 0.0006) were independent variables of survival. Loss of 2p21-16.3 was, moreover, associated with increased loss of the other tumour suppressor loci (P = 0.012).CONCLUSIONS: The results show that loss of 2p21-16.3 is an independent indicator of survival in patients with colorectal cancer.
KW - Adenocarcinoma/genetics
KW - Alleles
KW - Analysis of Variance
KW - Chromosomes, Human, Pair 21/genetics
KW - Colorectal Neoplasms/genetics
KW - Female
KW - Genetic Markers
KW - Humans
KW - Loss of Heterozygosity/genetics
KW - Male
KW - Microsatellite Repeats
KW - Multivariate Analysis
KW - Neoplasm Staging
KW - Predictive Value of Tests
KW - Prognosis
KW - Prospective Studies
KW - Sensitivity and Specificity
KW - Survival Analysis
U2 - 10.1080/003655201300051252
DO - 10.1080/003655201300051252
M3 - Journal article
C2 - 11336166
SN - 0036-5521
VL - 36
SP - 405
EP - 409
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
IS - 4
ER -