Alkamides from Phyllanthus fraternus

A A Sittie; E Lemmich; C E Olsen; L Hviid; S Brøgger Christensen

doi:10.1055/s-2006-957405

Alkamides from Phyllanthus fraternus

A A Sittie, E Lemmich, C E Olsen, L Hviid, S Brøgger Christensen

34 Citationer (Scopus)

Abstract

Two alkamides E,E-2,4-octadienamide and E,Z-2,4-decadienamide have been isolated from Phyllanthus fraternus, a plant used in Ghanaian traditional medicine to treat malaria. The compounds possess an alpha, beta, gamma, delta-unsaturated conjugated amide, a feature believed to enhance antiplasmodial activity. By means of an in vitro assay the two alkamides have been shown to possess moderate antiplasmodial activity.

Originalsprog	Engelsk
Tidsskrift	Planta Medica
Vol/bind	64
Udgave nummer	2
Sider (fra-til)	192-3
Antal sider	2
ISSN	0032-0943
DOI	https://doi.org/10.1055/s-2006-957405
Status	Udgivet - mar. 1998
Udgivet eksternt	Ja

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10.1055/s-2006-957405

Citationsformater

@article{aabcf8765d5d4398a411bceb55f6a852,

title = "Alkamides from Phyllanthus fraternus",

abstract = "Two alkamides E,E-2,4-octadienamide and E,Z-2,4-decadienamide have been isolated from Phyllanthus fraternus, a plant used in Ghanaian traditional medicine to treat malaria. The compounds possess an alpha, beta, gamma, delta-unsaturated conjugated amide, a feature believed to enhance antiplasmodial activity. By means of an in vitro assay the two alkamides have been shown to possess moderate antiplasmodial activity.",

keywords = "Amides/chemistry, Animals, Antiprotozoal Agents/chemistry, Humans, Leishmania major/drug effects, Lymphocyte Activation/drug effects, Lymphocytes/drug effects, Plants, Medicinal, Plasmodium falciparum/drug effects",

author = "Sittie, {A A} and E Lemmich and Olsen, {C E} and L Hviid and {Br{\o}gger Christensen}, S",

year = "1998",

month = mar,

doi = "10.1055/s-2006-957405",

language = "English",

volume = "64",

pages = "192--3",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

number = "2",

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TY - JOUR

T1 - Alkamides from Phyllanthus fraternus

AU - Sittie, A A

AU - Lemmich, E

AU - Olsen, C E

AU - Hviid, L

AU - Brøgger Christensen, S

PY - 1998/3

Y1 - 1998/3

N2 - Two alkamides E,E-2,4-octadienamide and E,Z-2,4-decadienamide have been isolated from Phyllanthus fraternus, a plant used in Ghanaian traditional medicine to treat malaria. The compounds possess an alpha, beta, gamma, delta-unsaturated conjugated amide, a feature believed to enhance antiplasmodial activity. By means of an in vitro assay the two alkamides have been shown to possess moderate antiplasmodial activity.

AB - Two alkamides E,E-2,4-octadienamide and E,Z-2,4-decadienamide have been isolated from Phyllanthus fraternus, a plant used in Ghanaian traditional medicine to treat malaria. The compounds possess an alpha, beta, gamma, delta-unsaturated conjugated amide, a feature believed to enhance antiplasmodial activity. By means of an in vitro assay the two alkamides have been shown to possess moderate antiplasmodial activity.

KW - Amides/chemistry

KW - Animals

KW - Antiprotozoal Agents/chemistry

KW - Humans

KW - Leishmania major/drug effects

KW - Lymphocyte Activation/drug effects

KW - Lymphocytes/drug effects

KW - Plants, Medicinal

KW - Plasmodium falciparum/drug effects

U2 - 10.1055/s-2006-957405

DO - 10.1055/s-2006-957405

M3 - Letter

C2 - 9525113

SN - 0032-0943

VL - 64

SP - 192

EP - 193

JO - Planta Medica

JF - Planta Medica

IS - 2

ER -

Alkamides from Phyllanthus fraternus

Abstract

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