Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Alemtuzumab treatment in Denmark: A national study based on the Danish Multiple Sclerosis Registry

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Leveraging Visual Outcome Measures to Advance Therapy Development in Neuroimmunologic Disorders

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Gastrointestinal bleeding and the risk of colorectal cancer in anticoagulated patients with atrial fibrillation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Fascicular heart blocks and risk of adverse cardiovascular outcomes: results from a large primary care population

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Ocrelizumab treatment in multiple sclerosis: A Danish population-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: To investigate clinical outcomes in a real-world setting in the complete population-based cohort of alemtuzumab-treated MS patients in Denmark.

METHODS: Data were retrieved from The Danish Multiple Sclerosis Registry between 2009 and 2019. Demographic and disease-specific patient parameters related to treatment history, efficacy, and safety outcomes were assessed at baseline and during follow-up visits.

RESULTS: A total of 209 patients (78% female) started treatment with alemtuzumab during the study period with 3.1 ± 1.4 years follow-up. After 2 years, 75% of patients were relapse-free compared to 48% the year before alemtuzumab (p < 0.001). The annual number of relapses was reduced by 69% in year 4 compared with the year prior alemtuzumab. More active disease before alemtuzumab increased the annual hazard rate for relapse (HR: 2.88, p < 0.001). The Expanded Disability Status Scale (EDSS) score remained stable or improved in 81% of patients after 2 years. The need for an additional treatment course was associated with higher number of relapses in the year before alemtuzumab (odds ratio (OR) = 1.95, p = 0.001).

CONCLUSION: In a country with primarily escalation strategy, relapse rate reduction was maintained for 5 years, and EDSS stabilized/improved in majority of patients. Higher relapse rate 1 year before alemtuzumab increased the odds for additional courses. Novel serious AEs were not observed.

OriginalsprogEngelsk
TidsskriftMultiple Sclerosis Journal
Vol/bind27
Udgave nummer14
Sider (fra-til)2254-2266
Antal sider13
ISSN1352-4585
DOI
StatusUdgivet - dec. 2021

ID: 72405494