Abstract
Recent studies have shown expression of the following regulatory WNK kinases in the kidney: the full-length WNK1 (L-WNK1), the shorter kidney specific WNK1 transcript (KS-WNK1), formed by alternative splicing, and WNK4. Aldosterone activates expression of KS-WNK1 and inhibits WNK4 via SGK1 - both leading to stimulation of ENaC and activation of ROMK, and increased potassium excretion. Thus, further characterization of the WNK system may lead to elucidation of the dual anti-natriuretic and kaliuretic effects of aldosterone, in situations where only activation of one of these effects is needed.
| Bidragets oversatte titel | The effect of aldosterone A on renal potassium excretion |
|---|---|
| Originalsprog | Dansk |
| Tidsskrift | Ugeskrift for Laeger |
| Vol/bind | 173 |
| Udgave nummer | 2 |
| Sider (fra-til) | 126-9 |
| Antal sider | 4 |
| ISSN | 0041-5782 |
| Status | Udgivet - 10 jan. 2011 |
| Udgivet eksternt | Ja |
Emneord
- Aldosterone
- Epithelial Sodium Channels
- Humans
- Immediate-Early Proteins
- Kidney Tubules
- Large-Conductance Calcium-Activated Potassium Channels
- Potassium
- Potassium Channels
- Potassium Channels, Inwardly Rectifying
- Protein-Serine-Threonine Kinases