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Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers: results from The BRCA1 and BRCA2 Cohort Consortium

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  • Hongyan Li
  • Mary Beth Terry
  • Antonis C Antoniou
  • Kelly-Anne Phillips
  • Karin Kast
  • Thea M Mooij
  • Christoph Engel
  • Catherine Noguès
  • Dominique Stoppa-Lyonnet
  • Christine Lasset
  • Pascaline Berthet
  • Veronique Mari
  • Olivier Caron
  • Daniel Barrowdale
  • Debra Frost
  • Carole Brewer
  • D Gareth Evans
  • Louise Izatt
  • Lucy Side
  • Lisa Walker
  • Marc Tischkowitz
  • Mark T Rogers
  • Mary E Porteous
  • Hanne E J Meijers-Heijboer
  • Johan Jp Gille
  • Marinus J Blok
  • Nicoline Hoogerbrugge
  • Mary B Daly
  • Irene L Andrulis
  • Saundra S Buys
  • Esther M John
  • Sue-Anne McLachlan
  • Michael Friedlander
  • Yen Y Tan
  • Ana Osorio
  • Trinidad Caldes
  • Anna Jakubowska
  • Jacques Simard
  • Christian F Singer
  • Edith Olah
  • Marie Navratilova
  • Lenka Foretova
  • Anne-Marie Gerdes
  • Marie-José Roos-Blom
  • Brita Arver
  • Håkan Olsson
  • Rita K Schmutzler
  • John L Hopper
  • Roger L Milne
  • Douglas F Easton
  • The BRCA1 and BRCA2 Cohort Consortium
Vis graf over relationer

BACKGROUND: Tobacco smoking and alcohol consumption have been intensively studied in the general population to assess their effects on the risk of breast cancer (BC), but very few studies have examined these effects in BRCA1 and BRCA2 mutation carriers. Given the high BC risk for mutation carriers and the importance of BRCA1 and BRCA2 in DNA repair, better evidence on the associations of these lifestyle factors with BC risk is essential.

METHODS: Using a large international pooled cohort of BRCA1 and BRCA2 mutation carriers, we conducted retrospective (5,707 BRCA1 mutation carriers; 3,525 BRCA2 mutation carriers) and prospective (2,276 BRCA1 mutation carriers; 1,610 BRCA2 mutation carriers) analyses of alcohol and tobacco consumption using Cox proportional hazards models.

RESULTS: For both BRCA1 and BRCA2 mutation carriers, none of the smoking-related variables was associated with BC risk, except smoking for more than five years before a first full-term pregnancy (FFTP) when compared to parous women who never smoked. For BRCA1 mutation carriers, the HR from retrospective analysis (HRR) was 1.19 (95%CI:1.02,1.39) and the HR from prospective analysis (HRP) was 1.36 (95%CI:0.99,1.87). For BRCA2 mutation carriers, smoking for more than five years before a FFTP showed an association of a similar magnitude, but the confidence limits were wider (HRR=1.25,95%CI:1.01,1.55 and HRP=1.30,95%CI:0.83,2.01). For both carrier groups, alcohol consumption was not associated with BC risk.

CONCLUSIONS: The finding that smoking during the pre-reproductive years increases BC risk for mutation carriers warrants further investigation.

IMPACT: This is the largest prospective study of BRCA mutation carriers to assess these important risk factors.

OriginalsprogEngelsk
TidsskriftCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Vol/bind29
Udgave nummer2
Sider (fra-til)368-378
ISSN1055-9965
DOI
StatusUdgivet - 1 feb. 2020

Bibliografisk note

Copyright ©2019, American Association for Cancer Research.

ID: 58956622