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Alcohol and delirium tremens: effects of average number of drinks per day and beverage type

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@article{0cb8a7bd782045e783ce65982dc6998e,
title = "Alcohol and delirium tremens: effects of average number of drinks per day and beverage type",
abstract = "Objective: Associations of amount of alcohol intake and beverage type with the risk of delirium tremens (DT) have not been studied. This longitudinal study investigated if the average number of drinks per day and beverage type predict DT. Methods: A cohort of 3 582 alcohol-dependent men and women aged 19–82 without previous DT were interviewed about alcohol intake and beverage type at baseline in 1994–2005 and followed through record linkage in Danish nationwide registers to identify incident DT. Data were analyzed by means of Cox regression models. Results: An average number of drinks per day of 20–30 or >30 was associated with hazard ratios (HRs) of 1.38 (95{\%} CI 1.03–1.84) and 1.64 (95{\%} CI 1.19–2.27) relative to the reference category (1–9 drinks). Independently of amount consumed and covariates (age, gender, civil status and work status), beverage type (spirits vs. mixed alcohol) was associated with a HR of 1.63 (95{\%} CI 1.08–2.46). Male gender was robustly associated with increased risk (HR = 1.62 (95{\%} CI 1.25–2.08). Conclusions: In alcohol-dependent men and women, daily alcohol intake above a threshold of 20 beverages or 240 g alcohol and a preference for spirits increase the risk of developing DT.",
keywords = "alcohol, delirium, risk factors, substance use disorders",
author = "S{\o}rensen, {Holger J} and Charlotte Holst and Joachim Knop and Mortensen, {Erik L} and Tolstrup, {Janne S} and Ulrik Becker",
note = "{\circledC} 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2019",
month = "6",
doi = "10.1111/acps.13006",
language = "English",
volume = "139",
pages = "518--525",
journal = "Acta Psychiatrica Scandinavica",
issn = "0001-690X",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - Alcohol and delirium tremens

T2 - effects of average number of drinks per day and beverage type

AU - Sørensen, Holger J

AU - Holst, Charlotte

AU - Knop, Joachim

AU - Mortensen, Erik L

AU - Tolstrup, Janne S

AU - Becker, Ulrik

N1 - © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2019/6

Y1 - 2019/6

N2 - Objective: Associations of amount of alcohol intake and beverage type with the risk of delirium tremens (DT) have not been studied. This longitudinal study investigated if the average number of drinks per day and beverage type predict DT. Methods: A cohort of 3 582 alcohol-dependent men and women aged 19–82 without previous DT were interviewed about alcohol intake and beverage type at baseline in 1994–2005 and followed through record linkage in Danish nationwide registers to identify incident DT. Data were analyzed by means of Cox regression models. Results: An average number of drinks per day of 20–30 or >30 was associated with hazard ratios (HRs) of 1.38 (95% CI 1.03–1.84) and 1.64 (95% CI 1.19–2.27) relative to the reference category (1–9 drinks). Independently of amount consumed and covariates (age, gender, civil status and work status), beverage type (spirits vs. mixed alcohol) was associated with a HR of 1.63 (95% CI 1.08–2.46). Male gender was robustly associated with increased risk (HR = 1.62 (95% CI 1.25–2.08). Conclusions: In alcohol-dependent men and women, daily alcohol intake above a threshold of 20 beverages or 240 g alcohol and a preference for spirits increase the risk of developing DT.

AB - Objective: Associations of amount of alcohol intake and beverage type with the risk of delirium tremens (DT) have not been studied. This longitudinal study investigated if the average number of drinks per day and beverage type predict DT. Methods: A cohort of 3 582 alcohol-dependent men and women aged 19–82 without previous DT were interviewed about alcohol intake and beverage type at baseline in 1994–2005 and followed through record linkage in Danish nationwide registers to identify incident DT. Data were analyzed by means of Cox regression models. Results: An average number of drinks per day of 20–30 or >30 was associated with hazard ratios (HRs) of 1.38 (95% CI 1.03–1.84) and 1.64 (95% CI 1.19–2.27) relative to the reference category (1–9 drinks). Independently of amount consumed and covariates (age, gender, civil status and work status), beverage type (spirits vs. mixed alcohol) was associated with a HR of 1.63 (95% CI 1.08–2.46). Male gender was robustly associated with increased risk (HR = 1.62 (95% CI 1.25–2.08). Conclusions: In alcohol-dependent men and women, daily alcohol intake above a threshold of 20 beverages or 240 g alcohol and a preference for spirits increase the risk of developing DT.

KW - alcohol

KW - delirium

KW - risk factors

KW - substance use disorders

UR - http://www.scopus.com/inward/record.url?scp=85061925117&partnerID=8YFLogxK

U2 - 10.1111/acps.13006

DO - 10.1111/acps.13006

M3 - Journal article

VL - 139

SP - 518

EP - 525

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

IS - 6

ER -

ID: 56412899