TY - JOUR
T1 - Aging of the brain in bipolar disorder
T2 - Illness- and onset-related effects in cortical thickness and subcortical gray matter volume
AU - Villa, Luca M
AU - Colic, Lejla
AU - Kim, Jihoon A
AU - Sankar, Anjali
AU - Goldman, Danielle A
AU - Lessing, Brandon
AU - Pittman, Brian
AU - Alexopoulos, George S
AU - van Dyck, Christopher H
AU - Blumberg, Hilary P
N1 - Copyright © 2022. Published by Elsevier B.V.
PY - 2023
Y1 - 2023
N2 - BACKGROUND: Older adults with bipolar disorder (BD) have received little study, although they often have severe symptoms, treatment resistance and high suicide risk. Furthermore, a subset develops cognitive dysfunction for unknown reasons.METHODS: Here, cortical thickness and subcortical gray matter volume were compared across individuals ages 40-79y: 103 with BD ("later-onset" at ages ≥25y, n = 21; "early-onset" <25y, n = 82) and healthy controls (HCs, n = 98).RESULTS: Overall, those with BD showed lower prefrontal, cingulate, sensorimotor, parahippocampal, insula, temporal, parietal, and occipital cortical thickness (Cohen's d: 0.4 to 0.8) and hippocampal, amygdalar, thalamic, and striatal gray matter volume (d: 0.6 to 0.8). Later-onset BD showed negative relationships between age and parahippocampal, insular, temporal, parietal, and occipital cortical thickness, and hippocampal, thalamic and striatal volume (r: -0.7 to -0.4). Suicide attempt history was associated with lower dorsolateral prefrontal cortical thickness (d = 0.5).LIMITATIONS: The study used a cross-sectional design and the sample of those with a later-onset of BD was relatively modest.CONCLUSIONS: Results support widespread gray matter decreases in older adults with BD, and also suggest a separable later-onset phenotype characterized by age-related gray matter reductions in regions subserving cognitive, emotional and perceptual processes. Moreover, the results are the first to demonstrate structural brain differences associated with a history of suicide attempts in older adults with BD.
AB - BACKGROUND: Older adults with bipolar disorder (BD) have received little study, although they often have severe symptoms, treatment resistance and high suicide risk. Furthermore, a subset develops cognitive dysfunction for unknown reasons.METHODS: Here, cortical thickness and subcortical gray matter volume were compared across individuals ages 40-79y: 103 with BD ("later-onset" at ages ≥25y, n = 21; "early-onset" <25y, n = 82) and healthy controls (HCs, n = 98).RESULTS: Overall, those with BD showed lower prefrontal, cingulate, sensorimotor, parahippocampal, insula, temporal, parietal, and occipital cortical thickness (Cohen's d: 0.4 to 0.8) and hippocampal, amygdalar, thalamic, and striatal gray matter volume (d: 0.6 to 0.8). Later-onset BD showed negative relationships between age and parahippocampal, insular, temporal, parietal, and occipital cortical thickness, and hippocampal, thalamic and striatal volume (r: -0.7 to -0.4). Suicide attempt history was associated with lower dorsolateral prefrontal cortical thickness (d = 0.5).LIMITATIONS: The study used a cross-sectional design and the sample of those with a later-onset of BD was relatively modest.CONCLUSIONS: Results support widespread gray matter decreases in older adults with BD, and also suggest a separable later-onset phenotype characterized by age-related gray matter reductions in regions subserving cognitive, emotional and perceptual processes. Moreover, the results are the first to demonstrate structural brain differences associated with a history of suicide attempts in older adults with BD.
KW - Age of onset
KW - Aging
KW - Bipolar disorder
KW - Cortical thickness
KW - Gray matter volume
UR - http://www.scopus.com/inward/record.url?scp=85144785997&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2022.12.026
DO - 10.1016/j.jad.2022.12.026
M3 - Journal article
C2 - 36526112
SN - 0165-0327
VL - 323
SP - 875
EP - 883
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -