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Aging and the evolution of comorbidities among HIV-positive individuals in a European cohort

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@article{baae68f337df4bbfa64747eeaeb8112c,
title = "Aging and the evolution of comorbidities among HIV-positive individuals in a European cohort",
abstract = "OBJECTIVES: To describe changes in the prevalence of comorbidities and risk factors among HIV-positive individuals in the EuroSIDA study.DESIGN: Comparison of two cross-sectional cohorts of HIV-positive adults under active follow-up in 2006 and 2014.METHODS: Baseline demographics and prevalence of comorbidities were described. Factors associated with the prevalence of chronic kidney disease (CKD) and cardiovascular disease (CVD) were assessed by logistic regression modelling using generalised estimating equations.RESULTS: 9798 individuals were under active follow-up in EuroSIDA during 2006 and 12882 during 2014. Compared to study participants in 2006, those in 2014 were older [median age 48.6 years, (IQR 40.3-55.1) v 43.1 years (37.2-50.0) in 2006] and had higher prevalence of hypertension (59.6{\%} v 47{\%} in 2006), diabetes (6.3{\%} v 5.4{\%}), CKD (6.9{\%} v 4.1{\%}) and CVD (5.0{\%} v 3.7{\%}). Individuals in the 2014 cohort had higher odds for CKD (unadjusted OR 2.62, 95{\%} CI 2.30-2.99, P < 0.0001) and CVD (OR 1.88, CI 1.68-2.10, P < 0.0001), but after multivariable adjustment for age group, comorbidities and other factors, year of cohort was no longer significantly associated with the odds of CKD (adjusted OR (aOR) 0.97, CI 0.52-1.82 P=0.92) or of CVD (aOR 0.94, CI 0.54-1.63, P = 0.82).CONCLUSIONS: Between 2006 and 2014 the population aged and experienced an overall higher prevalence of non-AIDS comorbidities, including CKD and CVD. The increase in CVD could be explained by the aging population, and the increase in CKD by aging and changes in other factors. Treatment strategies balancing HIV outcomes with long-term management of comorbidities remain a priority.",
author = "Annegret Pelchen-Matthews and Lene Ryom and Borges, {{\'A}lvaro H} and Simon Edwards and Claudine Duvivier and Christoph Stephan and Helen Sambatakou and Katarzyna Maciejewska and Portu, {Jos{\'e} Joaqu{\'i}n} and Jonathan Weber and Olaf Degen and Alexandra Calmy and Reikvam, {Dag Henrik} and Djordje Jevtovic and Lothar Wiese and Jelena Smidt and Tomasz Smiatacz and Gamal Hassoun and Anastasiia Kuznetsova and Bonaventura Clotet and Jens Lundgren and Amanda Mocroft and {EuroSIDA study}",
year = "2018",
month = "11",
day = "21",
doi = "10.1097/QAD.0000000000001967",
language = "English",
pages = "2405--2416",
journal = "AIDS",
issn = "0269-9370",
publisher = "Lippincott Williams & Wilkins",

}

RIS

TY - JOUR

T1 - Aging and the evolution of comorbidities among HIV-positive individuals in a European cohort

AU - Pelchen-Matthews, Annegret

AU - Ryom, Lene

AU - Borges, Álvaro H

AU - Edwards, Simon

AU - Duvivier, Claudine

AU - Stephan, Christoph

AU - Sambatakou, Helen

AU - Maciejewska, Katarzyna

AU - Portu, José Joaquín

AU - Weber, Jonathan

AU - Degen, Olaf

AU - Calmy, Alexandra

AU - Reikvam, Dag Henrik

AU - Jevtovic, Djordje

AU - Wiese, Lothar

AU - Smidt, Jelena

AU - Smiatacz, Tomasz

AU - Hassoun, Gamal

AU - Kuznetsova, Anastasiia

AU - Clotet, Bonaventura

AU - Lundgren, Jens

AU - Mocroft, Amanda

AU - EuroSIDA study

PY - 2018/11/21

Y1 - 2018/11/21

N2 - OBJECTIVES: To describe changes in the prevalence of comorbidities and risk factors among HIV-positive individuals in the EuroSIDA study.DESIGN: Comparison of two cross-sectional cohorts of HIV-positive adults under active follow-up in 2006 and 2014.METHODS: Baseline demographics and prevalence of comorbidities were described. Factors associated with the prevalence of chronic kidney disease (CKD) and cardiovascular disease (CVD) were assessed by logistic regression modelling using generalised estimating equations.RESULTS: 9798 individuals were under active follow-up in EuroSIDA during 2006 and 12882 during 2014. Compared to study participants in 2006, those in 2014 were older [median age 48.6 years, (IQR 40.3-55.1) v 43.1 years (37.2-50.0) in 2006] and had higher prevalence of hypertension (59.6% v 47% in 2006), diabetes (6.3% v 5.4%), CKD (6.9% v 4.1%) and CVD (5.0% v 3.7%). Individuals in the 2014 cohort had higher odds for CKD (unadjusted OR 2.62, 95% CI 2.30-2.99, P < 0.0001) and CVD (OR 1.88, CI 1.68-2.10, P < 0.0001), but after multivariable adjustment for age group, comorbidities and other factors, year of cohort was no longer significantly associated with the odds of CKD (adjusted OR (aOR) 0.97, CI 0.52-1.82 P=0.92) or of CVD (aOR 0.94, CI 0.54-1.63, P = 0.82).CONCLUSIONS: Between 2006 and 2014 the population aged and experienced an overall higher prevalence of non-AIDS comorbidities, including CKD and CVD. The increase in CVD could be explained by the aging population, and the increase in CKD by aging and changes in other factors. Treatment strategies balancing HIV outcomes with long-term management of comorbidities remain a priority.

AB - OBJECTIVES: To describe changes in the prevalence of comorbidities and risk factors among HIV-positive individuals in the EuroSIDA study.DESIGN: Comparison of two cross-sectional cohorts of HIV-positive adults under active follow-up in 2006 and 2014.METHODS: Baseline demographics and prevalence of comorbidities were described. Factors associated with the prevalence of chronic kidney disease (CKD) and cardiovascular disease (CVD) were assessed by logistic regression modelling using generalised estimating equations.RESULTS: 9798 individuals were under active follow-up in EuroSIDA during 2006 and 12882 during 2014. Compared to study participants in 2006, those in 2014 were older [median age 48.6 years, (IQR 40.3-55.1) v 43.1 years (37.2-50.0) in 2006] and had higher prevalence of hypertension (59.6% v 47% in 2006), diabetes (6.3% v 5.4%), CKD (6.9% v 4.1%) and CVD (5.0% v 3.7%). Individuals in the 2014 cohort had higher odds for CKD (unadjusted OR 2.62, 95% CI 2.30-2.99, P < 0.0001) and CVD (OR 1.88, CI 1.68-2.10, P < 0.0001), but after multivariable adjustment for age group, comorbidities and other factors, year of cohort was no longer significantly associated with the odds of CKD (adjusted OR (aOR) 0.97, CI 0.52-1.82 P=0.92) or of CVD (aOR 0.94, CI 0.54-1.63, P = 0.82).CONCLUSIONS: Between 2006 and 2014 the population aged and experienced an overall higher prevalence of non-AIDS comorbidities, including CKD and CVD. The increase in CVD could be explained by the aging population, and the increase in CKD by aging and changes in other factors. Treatment strategies balancing HIV outcomes with long-term management of comorbidities remain a priority.

U2 - 10.1097/QAD.0000000000001967

DO - 10.1097/QAD.0000000000001967

M3 - Journal article

SP - 2405

EP - 2416

JO - AIDS

JF - AIDS

SN - 0269-9370

ER -

ID: 55338504