Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Age-dependent impairment of the erythropoietin response to reduced central venous pressure in HFpEF patients

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Glucagon-like peptide-1 elicts vasodilation in adipose tissue and skeletal muscle in healthy men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Diagnosing von Willebrand disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Procholecystokinin expression and processing in cardiac myocytes

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Serum proatrial natriuretic peptide concentrations during oral glucose-induced acute hyperinsulinemia in lean and obese men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Adjunctive dabigatran therapy improves outcome of experimental left-sided Staphylococcus aureus endocarditis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Despite growing research interest in the pathophysiology of heart failure with preserved ejection fraction (HFpEF), it remains unknown whether central hemodynamic alterations inherently present in this condition do affect blood pressure and blood volume (BV) regulation. The present study sought to determine hemodynamic and endocrine responses to prolonged orthostatic stress in HFpEF patients. Central venous pressure (CVP) assessed via the internal jugular vein (IJV) aspect ratio with ultrasonography, arterial pressure and heart rate were determined at supine rest and during 2 hours of moderate (25-30°) head-up tilt (HUT) in 18 stable HFpEF patients (71.2 ± 7.3 years), 14 elderly (EC), and 10 young (YC) healthy controls. Parallel endocrine measurements comprised main BV-regulating hormones: pro-atrial natriuretic peptide, copeptin, aldosterone, and erythropoietin (EPO). At supine rest, the IJV aspect ratio was higher (>30%) in HFpEF patients compared with EC and YC, while mean arterial pressure was elevated in HFpEF patients (98.0 ± 13.1 mm Hg) and EC (95.6 ± 8.3 mm Hg) versus YC (87.3 ± 5.0 mm Hg) (P < 0.05). HUT increased heart rate (+10%) and reduced the IJV aspect ratio (-52%), with similar hemodynamic effects in all groups (P for interaction ≥ 0.322). The analysis of endocrine responses to HUT revealed a group×time interaction for circulating EPO, which was increased in YC (+10%) but remained unaltered in HFpEF patients and EC. The EPO response to a given reduction in CVP is similarly impaired in HFpEF patients and elderly controls, suggesting an age-dependent dissociation of EPO production from hemodynamic regulation in the HFpEF condition.

TidsskriftPhysiological Reports
Udgave nummer5
Antal sider10
StatusUdgivet - mar. 2019

Bibliografisk note

© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

ID: 56921716