TY - JOUR
T1 - Age-Specific Estimates of Respiratory Syncytial Virus-Associated Hospitalizations in 6 European Countries
T2 - A Time Series Analysis
AU - Johannesen, Caroline K
AU - van Wijhe, Maarten
AU - Tong, Sabine
AU - Fernández, Liliana V
AU - Heikkinen, Terho
AU - van Boven, Michiel
AU - Wang, Xin
AU - Bøås, Håkon
AU - Li, You
AU - Campbell, Harry
AU - Paget, John
AU - Stona, Luca
AU - Teirlinck, Anne
AU - Lehtonen, Toni
AU - Nohynek, Hanna
AU - Bangert, Mathieu
AU - Fischer, Thea K
AU - RESCEU Investigators
N1 - © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2022/8/12
Y1 - 2022/8/12
N2 - BACKGROUND: Knowledge on age-specific hospitalizations associated with RSV infection is limited due to limited testing, especially in older children and adults in whom RSV infections are not expected to be severe. Burden estimates based on RSV coding of hospital admissions are known to underestimate the burden of RSV. We aimed to provide robust and reliable age-specific burden estimates of RSV-associated hospital admissions based on data on respiratory infections from national health registers and laboratory-confirmed cases of RSV.METHODS: We conducted multiseason regression analysis of weekly hospitalizations with respiratory infection and weekly laboratory-confirmed cases of RSV and influenza as covariates, based on national health registers and laboratory databases across 6 European countries. The burden of RSV-associated hospitalizations was estimated by age group, clinical diagnosis, and presence of underlying medical conditions.RESULTS: Across the 6 European countries, hospitalizations of children with respiratory infections were clearly associated with RSV, with associated proportions ranging from 28% to 60% in children younger than 3 months and we found substantial proportions of admissions to hospital with respiratory infections associated with RSV in children younger than 3 years. Associated proportions were highest among hospitalizations with ICD-10 codes of "bronchitis and bronchiolitis." In all 6 countries, annual incidence of RSV-associated hospitalizations was >40 per 1000 persons in the age group 0-2 months. In age group 1-2 years the incidence rate ranged from 1.3 to 10.5 hospitalizations per 1000. Adults older than 85 years had hospitalizations with respiratory infection associated to RSV in all 6 countries although incidence rates were low.CONCLUSIONS: Our findings highlight the substantial proportion of RSV infections among hospital admissions across different ages and may help public health professionals and policy makers when planning prevention and control strategies. In addition, our findings provide valuable insights for health care professionals attending to both children and adults presenting with symptoms of viral respiratory infections.
AB - BACKGROUND: Knowledge on age-specific hospitalizations associated with RSV infection is limited due to limited testing, especially in older children and adults in whom RSV infections are not expected to be severe. Burden estimates based on RSV coding of hospital admissions are known to underestimate the burden of RSV. We aimed to provide robust and reliable age-specific burden estimates of RSV-associated hospital admissions based on data on respiratory infections from national health registers and laboratory-confirmed cases of RSV.METHODS: We conducted multiseason regression analysis of weekly hospitalizations with respiratory infection and weekly laboratory-confirmed cases of RSV and influenza as covariates, based on national health registers and laboratory databases across 6 European countries. The burden of RSV-associated hospitalizations was estimated by age group, clinical diagnosis, and presence of underlying medical conditions.RESULTS: Across the 6 European countries, hospitalizations of children with respiratory infections were clearly associated with RSV, with associated proportions ranging from 28% to 60% in children younger than 3 months and we found substantial proportions of admissions to hospital with respiratory infections associated with RSV in children younger than 3 years. Associated proportions were highest among hospitalizations with ICD-10 codes of "bronchitis and bronchiolitis." In all 6 countries, annual incidence of RSV-associated hospitalizations was >40 per 1000 persons in the age group 0-2 months. In age group 1-2 years the incidence rate ranged from 1.3 to 10.5 hospitalizations per 1000. Adults older than 85 years had hospitalizations with respiratory infection associated to RSV in all 6 countries although incidence rates were low.CONCLUSIONS: Our findings highlight the substantial proportion of RSV infections among hospital admissions across different ages and may help public health professionals and policy makers when planning prevention and control strategies. In addition, our findings provide valuable insights for health care professionals attending to both children and adults presenting with symptoms of viral respiratory infections.
KW - respiratory syncytial virus
KW - viral hospitalizations
KW - burden of disease
KW - RSV
KW - public health
KW - time series analysis
KW - Age Factors
KW - Humans
KW - Respiratory Syncytial Virus, Human
KW - Child, Preschool
KW - Infant
KW - Hospitalization
KW - Respiratory Tract Infections/epidemiology
KW - Respiratory Syncytial Virus Infections/epidemiology
KW - Time Factors
KW - Adult
KW - Child
KW - Infant, Newborn
UR - http://www.scopus.com/inward/record.url?scp=85141532278&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiac150
DO - 10.1093/infdis/jiac150
M3 - Journal article
C2 - 35748871
SN - 0022-1899
VL - 226
SP - S29-S37
JO - The Journal of infectious diseases
JF - The Journal of infectious diseases
IS - Suppl 1
ER -